CLINICAL TRIAL: HALT-C

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 据估计，美国有400万人感染丙型肝炎，每年新增确诊病例3万例(1-3例)。在导致肝脏疾病的原因中，丙型肝炎病毒排在第二位，仅次于酒精中毒，是肝脏移植的主要原因(4-6)。卫生专家说，死于丙型肝炎病毒的人数可能很快就会超过被归因于艾滋病的人数(梅奥诊所，1998年12月12日)。事实上，在发达国家，丙型肝炎可能是导致原发性肝癌的最常见原因。在意大利、西班牙和日本，至少一半的肝癌可能与丙型肝炎病毒有关。慢性丙型肝炎可导致肝硬化、肝功能衰竭和肝癌(8)。大约20%的患者在感染后10到20年内发展为肝硬变(9)。男性、酗酒者、肝硬变患者、40岁以上的人以及感染20到40年的人更容易患上与丙型肝炎病毒相关的肝癌(7)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hepatitis C affects an estimated 4 million people in the U.S., with 30,000 new cases diagnosed annually (1-3). The hepatitis C virus (HCV) ranks second behind alcoholism among the causes of liver disease and is the leading reason for liver transplants (4-6). Health experts say the number of deaths from HCV may soon surpass the number attributed to AIDS (Mayo Clinic, Dec. 12, 1998). In fact, hepatitis C might be the most common cause of primary liver cancer in the developed world. In Italy, Spain, and Japan, at least half of liver cancers could be related to HCV (7). Chronic hepatitis C can cause cirrhosis, liver failure, and liver cancer (8). About 20 percent of patients develop cirrhosis within 10 to 20 years of the onset of infection (9). Men, alcoholics, patients with cirrhosis, people over age 40, and those infected for 20 to 40 years are more likely to develop HCV-related liver cancer (7).