METABOLIC RATE IN POSTMENOPAUSAL WOMEN - EFFECTS OF PHYSICAL ACTIVITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的主要目的是扩大关于体力活动对健康绝经后女性基础代谢率(BMR)影响的研究，并进一步比较长期习惯性运动的效果与较短期(16周)训练计划的结果。我们将通过间接热量来测量BMR，并将其在不同受试者的体型(无脂肪质量)和有氧健身水平(VO2max)上归一化。将三组进行比较：久坐对照组(从未参加过规律运动)、既往久坐干预组(既往无规律运动，新参加本研究？S 16周训练计划)、长期运动员组(过去10年或更长时间每周至少参加5小时运动)。第二个目标是生成一个回归方程，用于从体力活动的绝经后妇女的无脂肪质量预测BMR，并应用于生物人类学的假说。 我们期望在基线时发现，在控制无脂肪质量和最大摄氧量的情况下，对照组和干预组的BMR没有差异，而长期组的BMR明显更高。在16周时，我们预计对照组和长期组的基础代谢率没有变化，而干预组的基础代谢率将增加。同时，我们期望在对照组和干预组之间发现BMR的显著差异，并期望干预组的BMR与长期运动员的BMR相似。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary purpose of this study is to expand research on the effects of physical activity on basal metabolic rate (BMR) in healthy postmenopausal women, and to further compare the effects of long-term habitual exercise to the results of a shorter-term (16 weeks) training program. We will measure BMR by indirect calorimtery and normalize it across subjects for body size (fat free mass) and level of aerobic fitness (VO2MAX). Three groups will be compared: sedentary control group (never participated in regular exercise), formerly sedentary intervention group (no previous participation in regular exercise, newly enrolled in this study?s 16 week training program), long-term athlete group (have engaged in at least 5 hours of exercise per week for the past 10 years or longer). A secondary aim is to generate a regression equation for the prediction of BMR from fat free mass in physically active postmenopausal women, to be applied to hypotheses in biological anthropology. We expect to find at baseline that, controlling for fat free mass and VO2MAX, the control and intervention groups will not differ in BMR, while the long-term group will have significantly higher BMR. At 16 weeks we expect no change in BMR for the control and long-term groups, while BMR will have increased in the intervention group. At the same time, we expect to find a significant difference in BMR between the control and intervention groups, and expect that the intervention group will have BMR similar to that of the long-term athletes.