METABOLIC RATE IN POSTMENOPAUSAL WOMEN - EFFECTS OF PHYSICAL ACTIVITY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的主要目的是扩大对健康绝经后妇女身体活动对基础代谢率（BMR）的影响的研究，并进一步比较长期习惯性运动与短期（16周）训练计划的效果。我们将通过间接量热法测量BMR，并根据受试者的体型（无脂肪质量）和有氧健身水平（VO 2 MAX）对其进行标准化。将比较三组：久坐对照组（从未参加过常规运动），原久坐干预组（从未参加过常规运动，新入组本研究？16周训练计划），长期运动员组（在过去10年或更长时间内每周至少锻炼5小时）。第二个目的是产生一个回归方程的预测BMR从身体活动的绝经后妇女的脂肪质量，以应用于生物人类学的假设。 我们期望在基线时发现，控制去脂质量和VO 2 MAX，对照组和干预组的基础代谢率没有差异，而长期组的基础代谢率将显著更高。在16周时，我们预计对照组和长期组的基础代谢率没有变化，而干预组的基础代谢率将增加。同时，我们期望发现控制组和干预组之间的基础代谢率有显著差异，并期望干预组的基础代谢率与长期运动员的基础代谢率相似。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary purpose of this study is to expand research on the effects of physical activity on basal metabolic rate (BMR) in healthy postmenopausal women, and to further compare the effects of long-term habitual exercise to the results of a shorter-term (16 weeks) training program. We will measure BMR by indirect calorimtery and normalize it across subjects for body size (fat free mass) and level of aerobic fitness (VO2MAX). Three groups will be compared: sedentary control group (never participated in regular exercise), formerly sedentary intervention group (no previous participation in regular exercise, newly enrolled in this study?s 16 week training program), long-term athlete group (have engaged in at least 5 hours of exercise per week for the past 10 years or longer). A secondary aim is to generate a regression equation for the prediction of BMR from fat free mass in physically active postmenopausal women, to be applied to hypotheses in biological anthropology. We expect to find at baseline that, controlling for fat free mass and VO2MAX, the control and intervention groups will not differ in BMR, while the long-term group will have significantly higher BMR. At 16 weeks we expect no change in BMR for the control and long-term groups, while BMR will have increased in the intervention group. At the same time, we expect to find a significant difference in BMR between the control and intervention groups, and expect that the intervention group will have BMR similar to that of the long-term athletes.