CLINICAL TRIAL: SWOG S0000: SELENIUM AND VITAMIN E CANCER PREVENTION TRIAL (SEL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在过去的十年里，前列腺癌一直是美国男性最常见的恶性肿瘤（不包括非黑色素瘤皮肤癌）。 据估计，高加索男性发生前列腺癌的终生风险为16.6%，非洲裔美国男性为18.1%，50岁男性的总体前列腺癌死亡风险为2.9%（Ries，et. 1998，Scher; et. 1995）。 降低前列腺癌死亡率和发病率的理想方法是通过一级预防：通过减少危及生命的临床明显病例的数量或通过降低疾病发展的年龄依赖性速率，即，这种疾病会比其他情况下晚5年、10年、15年变得明显。 虽然有证据表明这种肿瘤的发展可能与饮食习惯有关，但改变这种行为模式的问题和终身干预的需要使得这种预防方法在实践中很困难（Mishina，et.例如，1985年）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prostate cancer has been the most common malignant tumor (excluding non-melanoma skin cancer) in U.S. men for the last decade. It has been estimated that the lifetime risk of developing prostate cancer is 16.6% for Caucasian males and 18.1% for African-American males, and the overall prostate cancer mortality risk for men age 50 is 2.9% (Ries, et. al. 1998, Scher; et. al. 1995). An ideal method to reduce the mortality and morbidity of carcinoma of the prostate would be through primary prevention: either through a reduction in the number of life-threatening, clinically-evident cases or through a reduced age-dependent rate of development of the disease, i.e., the disease would become evident 5, 10, 15 years later than otherwise would occur. Although there is evidence that the development of this tumor may be related to dietary habits, problems in changing such patterns of behavior and the need for life-long intervention make such a preventative method difficult in practice (Mishina, et. al., 1985).