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Conference: Biology in the Age of Gene Editing: New Tools and Novel Insights into Organismal Biology and the Neural Basis of Behavior

会议：基因编辑时代的生物学：对有机体生物学和行为神经基础的新工具和新见解

基本信息

批准号：
2223926
负责人：
Scott Juntti
金额：
$ 1.28万
依托单位：
University of Maryland, College Park
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2022
资助国家：
美国
起止时间：
2022-12-01 至 2023-05-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2223926&HistoricalAwards=false
关键词：
Conference Biology Age Gene Editing

项目摘要

The genomic revolution has ushered in a new era of biological research. Genomes have been sequenced for not only humans and traditional laboratory animal models such as mice and fruit flies, but thousands of diverse organisms. However, to turn this data into a deep understanding of how genes function, scientists need the ability to manipulate these genes in the newly sequenced species. Recent years have seen dramatic technological improvements to genome editing in several of these species, enabling direct tests. An NSF-funded symposium at the Society for Integrative Biology (SICB) in Austin, TX in January 2023 will shine a spotlight on research in diverse species to reveal new principles of biological function. Work presented aims to accelerate development of these tools in additional species by gathering gene editing experts to teach their methods to others. Using tools like CRISPR/Cas9 gene editing, speakers have modified the genomes of species from jellyfish to mammals and many species in between. Studying many of the unique model organisms represented at SICB may have broad impacts including transformative knowledge advances, an understanding of ecologically important species, or medical insights. This symposium will help democratize gene editing tools to many species and advance knowledge of fundamental biological principles. The advent of genetic manipulations has enabled incredible insights into genetic mechanisms that control biological processes. However, it has also promoted the consolidation of research into a limited number of species (eg, fruit fly, mouse, zebrafish, C. elegans). As a result, the genetic regulation of a tremendous variety of evolutionary adaptations across species have been understudied at a mechanistic level. The development of CRISPR/Cas genome editing, in particular, enables an expansion of the number of species in which genetic experiments can be performed. Some progress has been made in using gene-edited species to understand organismal biology in ways inaccessible with traditional model organisms. The goal of this symposium is to catalyze the transfer of knowledge and skills from researchers who have applied these technologies in new model organisms to scientists who would like to bring these approaches to their own research programs. A symposium at the 2023 Society for Integrative and Comparative Biology (SICB) conference, which will feature talks, discussions, and a workshop. The speakers (who span institution types, locations, genders, along a spectrum of career stages) have modified species from jellyfish to mammals and many species in between. There will also be an educational event in which speakers from the symposium provide small-group consultations plus a panel discussion. To disseminate this work, all speakers have agreed to publish data presented at SICB in Integrative and Comparative Biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

基因组革命开创了生物学研究的新时代。不仅人类和传统的实验室动物模型（如小鼠和果蝇）的基因组已被测序，而且数千种不同的生物体也被测序。然而，为了将这些数据转化为对基因功能的深入理解，科学家需要能够在新测序的物种中操纵这些基因。近年来，在这些物种中，基因组编辑的技术有了巨大的进步，使直接测试成为可能。2023年1月在德克萨斯州奥斯汀举行的综合生物学学会（SICB）的NSF资助的研讨会将聚焦于不同物种的研究，以揭示生物功能的新原理。这项工作旨在通过召集基因编辑专家向其他人传授他们的方法来加速这些工具在其他物种中的开发。使用CRISPR/Cas9基因编辑等工具，演讲者已经修改了从水母到哺乳动物以及介于两者之间的许多物种的基因组。研究SICB代表的许多独特的模式生物可能会产生广泛的影响，包括变革性的知识进步，对生态重要物种的理解或医学见解。这次研讨会将有助于使基因编辑工具民主化，并促进基本生物学原理的知识。基因操纵的出现使人们对控制生物过程的遗传机制有了令人难以置信的了解。然而，它也促进了对有限物种（如果蝇、小鼠、斑马鱼、C. elegans）。因此，跨物种的各种进化适应的遗传调控在机械水平上研究不足。特别是CRISPR/Cas基因组编辑的发展，使得可以进行遗传实验的物种数量得以扩大。在使用基因编辑物种以传统模式生物无法达到的方式了解生物生物学方面取得了一些进展。本次研讨会的目标是促进知识和技能的转移，从那些在新的模式生物中应用这些技术的研究人员到那些希望将这些方法带入自己的研究计划的科学家。在2023年社会综合和比较生物学（SICB）会议，其中将包括讲座，讨论和研讨会的研讨会。演讲者（跨越机构类型、地点、性别、沿着一系列职业阶段）已经改变了从水母到哺乳动物的物种，以及介于两者之间的许多物种。还将举行一次教育活动，专题讨论会的发言者将提供小组协商和小组讨论。为了传播这项工作，所有发言人都同意发表在SICB的综合和比较生物学中提交的数据。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。