GENOMICS OF KIDNEY TRANSPLANTATION

肾移植的基因组学

• 批准号: 7951708
• 负责人: Pamala A Jacobson
• 金额: $ 0.37万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951708
• 关键词: Adverse effects; Biological; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Data; Drug Delivery Systems; Drug Kinetics; Enrollment; Enzymes; Funding; Genetic Predisposition to Disease; Genomics; Grant; Immune; Immunosuppressive Agents; Institution; Kidney; Kidney Transplantation; Link; Outcome; Pathway interactions; Pharmaceutical Preparations; Research; Research Personnel; Resources; Source; Testing; Transplant Recipients; United States National Institutes of Health; cohort; genetic epidemiology; genetic variant; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study proposes a genetic epidemiology approach using data, in part, collected by an ongoing, large, prospective cohort of kidney transplant recipients enrolled in a NIH-funded study (DeKAF). This study will determine how genetic predisposition may help to explain the outcomes defined in the DeKAF study. Specifically, this study will examine the link between genetic variants (SNPs), immune suppressant pharmacokinetics, adverse effects, and clinical outcomes. The overall objective is to test the relationship between specific genetic variants of drug metabolizing enzymes, drug transporters, drug targets and biological pathways associated with pharmacokinetics, adverse effects of immunosuppressants, and kidney rejection.

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