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Pharmacogenomics of Immune Suppressants in Kidney Transplantation

Pharmacogenomics of Immune Suppressants in Kidney Transplantation
肾移植中免疫抑制剂的药物基因组学
批准号：
8516962
负责人：
Pamala A Jacobson
金额：
$23.1万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
项目状态：
已结题
起止时间：
2013-08-01 至 2016-07-31
来源：
https://reporter.nih.gov/project-details/8516962
关键词：
AcuteAdverse effectsAffectAfrican AmericanAllograftingAnemiaBloodCalcineurin inhibitorCessation of lifeClinicalConflict (Psychology)CyclosporineDataDiabetes MellitusDialysis procedureDoseDrug KineticsDrug TargetingEffectivenessEnrollmentEventFailureGene ExpressionGenesGeneticGenetic DeterminismGenetic MarkersGenetic VariationGenomeGenomicsGoalsGraft SurvivalGrantImmuneImmunosuppressionImmunosuppressive AgentsIndividualInosineKidney TransplantationLeadLeukopeniaMetabolismModelingMonitorMycophenolateOutcomeOxidoreductasePatientsPharmaceutical PreparationsPharmacogenomicsPhenotypePreventionProteinsRaceRegimenRiskRisk FactorsSingle Nucleotide PolymorphismSteroidsTacrolimusTestingTherapeuticTherapeutic immunosuppressionToxic effectTransplant RecipientsTransplantationValidationadverse outcomeclinical practicedrug efficacyenzyme activitygenome wide association studyimprovedmRNA Expressionnephrotoxicitynovelprotein expressionretransplantationsuccess

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英文摘要
We propose to investigate the pharmacogenomics ofthe calcineurin inhibitors (CNI) and mycophenolate in kidney transplantation. Despite the tremendous therapeutic advances that these drugs have provided, their use is still limited by toxicities and therapy failures. Unfortunately, we are unable to discern which patients will develop toxicity or fail therapy. For these patients the consequences can be severe including return to dialysis, retransplantation and death. Monitoring of blood levels has improved our ability to improve and tailor therapy once immune suppression is initiated; however, initial doses are largely empiric and use the crude
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Pharmacogenomics of Immune Suppressants in Kidney Transplantation
  • 批准号：
    8224740
  • 项目类别：
  • 资助金额：
    $14.46万
  • 财政年份：
    2011
  • 负责人：
    Pamala A Jacobson
  • 依托单位：
    UNIVERSITY OF MINNESOTA
GENOMICS OF KIDNEY TRANSPLANTATION
  • 批准号：
    7951708
  • 项目类别：
  • 资助金额：
    $0.37万
  • 财政年份：
    2008
  • 负责人：
    Pamala A Jacobson
  • 依托单位：
    UNIVERSITY OF MINNESOTA
MT2003-24-FLUDARABINE PHARMACOKINETICS IN NONMYELOABLATIVE HEMATOPOIETIC CELL TR
  • 批准号：
    7606002
  • 项目类别：
  • 资助金额：
    $9.84万
  • 财政年份：
    2006
  • 负责人：
    Pamala A Jacobson
  • 依托单位：
    UNIVERSITY OF MINNESOTA
Pharmacogenetics of Immune Suppressants in Kidney Transplantation
  • 批准号：
    7148474
  • 项目类别：
  • 资助金额：
    $23.35万
  • 财政年份：
    2006
  • 负责人：
    Pamala A Jacobson
  • 依托单位：
    UNIVERSITY OF MINNESOTA
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