XENOBIOTIC BIOTRANSFORMATION IN CHILDREN WITH NONALCOHOLIC FATTY LIVER DISEASE

非酒精性脂肪肝病儿童的异生生物转化

• 批准号: 7951010
• 负责人: JOEL Edward LAVINE
• 金额: $ 0.74万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951010
• 关键词: Acetaminophen; Adolescent; CYP2D6 gene; CYP3A4 gene; Caffeine; Child; Clinical Research; Collection; Computer Retrieval of Information on Scientific Projects Database; Cytochrome P-450 CYP1A2; Enzymes; Funding; Grant; Institution; Liver diseases; Metabolic Biotransformation; Metabolism; Phase; Plasma; Population; Research; Research Personnel; Resources; Saliva; Sampling; Source; Transferase; United States National Institutes of Health; Urine; Xenobiotic Metabolism; Xenobiotics; absorption; base; non-alcoholic fatty liver

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The principle objective is to compare the activity of phase I and II enzymes in xenobiotic metabolism in adolescents with or without non-alcoholic fatty liver disease. Specifically, we would compare CYP 1A2, CYP2D6, CYP3A, glucuronyl-transferase (UGT) and sulfono-transferase (ST) activity between these two populations. Other objectives include: To estimate caffeine clearance using a single plasma sample, and CYP 1A2 activity based on urine collection; To determine the utility of saliva collection in determining absorption rate of caffeine and acetaminophen; To determine the utility of saliva collection in determining acetaminophen metabolism

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 主要目的是比较有或没有非酒精性脂肪肝的青少年中异生物质代谢的I相和II相酶的活性。具体而言，我们将比较这两个群体之间的CYP 1A 2，CYP 2D 6，CYP 3A，葡萄糖醛酸转移酶（UGT）和磺基转移酶（ST）活性。 其他目标包括： 使用单个血浆样本估计咖啡因清除率，并基于尿液收集估计β 1A 2活性;确定唾液收集在确定咖啡因和对乙酰氨基酚吸收率中的效用;确定唾液收集在确定对乙酰氨基酚代谢中的效用