XENOBIOTIC BIOTRANSFORMATION IN CHILDREN WITH NONALCOHOLIC FATTY LIVER DISEASE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 主要目的是比较有或没有非酒精性脂肪肝的青少年中异生物质代谢的I相和II相酶的活性。具体而言，我们将比较这两个群体之间的CYP 1A 2，CYP 2D 6，CYP 3A，葡萄糖醛酸转移酶（UGT）和磺基转移酶（ST）活性。 其他目标包括： 使用单个血浆样本估计咖啡因清除率，并基于尿液采集估计β 1A 2活性 确定唾液收集在测定咖啡因和对乙酰氨基酚吸收率中的效用 确定唾液采集在测定对乙酰氨基酚代谢中的效用

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The principle objective is to compare the activity of phase I and II enzymes in xenobiotic metabolism in adolescents with or without non-alcoholic fatty liver disease. Specifically, we would compare CYP 1A2, CYP2D6, CYP3A, glucuronyl-transferase (UGT) and sulfono-transferase (ST) activity between these two populations. Other objectives include: To estimate caffeine clearance using a single plasma sample, and CYP 1A2 activity based on urine collection To determine the utility of saliva collection in determining absorption rate of caffeine and acetaminophen To determine the utility of saliva collection in determining acetaminophen metabolism