XENOBIOTIC BIOTRANSFORMATION IN CHILDREN WITH NONALCOHOLIC FATTY LIVER DISEASE

非酒精性脂肪肝病儿童的异生生物转化

• 批准号: 8166859
• 负责人: JOEL Edward LAVINE
• 金额: $ 0.24万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166859
• 关键词: Acetaminophen; Adolescent; CYP2D6 gene; CYP3A4 gene; Caffeine; Child; Collection; Computer Retrieval of Information on Scientific Projects Database; Cytochrome P-450 CYP1A2; Enzymes; Funding; Grant; Institution; Liver diseases; Metabolic Biotransformation; Metabolism; Phase; Plasma; Population; Research; Research Personnel; Resources; Saliva; Sampling; Source; Transferase; United States National Institutes of Health; Urine; Xenobiotic Metabolism; Xenobiotics; absorption; base; non-alcoholic fatty liver

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The principle objective is to compare the activity of phase I and II enzymes in xenobiotic metabolism in adolescents with or without non-alcoholic fatty liver disease. Specifically, we would compare CYP 1A2, CYP2D6, CYP3A, glucuronyl-transferase (UGT) and sulfono-transferase (ST) activity between these two populations. Other objectives include: To estimate caffeine clearance using a single plasma sample, and CYP 1A2 activity based on urine collection To determine the utility of saliva collection in determining absorption rate of caffeine and acetaminophen To determine the utility of saliva collection in determining acetaminophen metabolism

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