XENOBIOTIC BIOTRANSFORMATION IN CHILDREN WITH NONALCOHOLIC FATTY LIVER DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 主要目的是比较患有或不患有非酒精性脂肪肝的青少年异物代谢中I相酶和II相酶的活性。具体地说，我们将比较这两个群体中的CyP1A2、CYP2D6、CyP3A、葡萄糖醛酸基转移酶(UGT)和磺基转移酶(ST)的活性。 其他目标包括： 使用单个血浆样本估计咖啡因清除量和基于尿液收集的CYP 1A2活性 唾液采集在咖啡因和对乙酰氨基酚吸收率测定中的应用 唾液采集在对乙酰氨基酚代谢检测中的应用

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The principle objective is to compare the activity of phase I and II enzymes in xenobiotic metabolism in adolescents with or without non-alcoholic fatty liver disease. Specifically, we would compare CYP 1A2, CYP2D6, CYP3A, glucuronyl-transferase (UGT) and sulfono-transferase (ST) activity between these two populations. Other objectives include: To estimate caffeine clearance using a single plasma sample, and CYP 1A2 activity based on urine collection To determine the utility of saliva collection in determining absorption rate of caffeine and acetaminophen To determine the utility of saliva collection in determining acetaminophen metabolism