TRIALNET NATURAL HISTORY STUDY OF THE DEVELOPMENT OF TYPE 1 DIABETES PHASE 1

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 1型糖尿病（T1 D）发展的TrialNet自然史研究的目标是获得有关T1 D发病机制和自然史的信息，并促进招募和评估可能有资格参加T1 D预防试验的个人。 重要的是，从这项研究中获得的信息将有助于制定和实施预防试验。 本研究的总体目标是随着时间的推移对T1 D风险个体的代谢和免疫状态进行基线和重复评估，以表征其发展T1 D的风险，描述T1 D的发病演变，并增加对T1 D发展中涉及的发病因素的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of the TrialNet Natural History Study of the Development of Type 1 Diabetes (T1D) are to both gain information about the pathogenesis and natural history of T1D and to facilitate the recruitment and assessment of individuals who might qualify for T1D prevention trials. Importantly, the information obtained from this study will serve to enable the development and implementation of prevention trials. The overall objective of this study is to perform baseline and repeat assessments over time of the metabolic and immunologic status of individuals at risk for T1D in order to characterize their risk for developing T1D, to describe the pathogenetic evolution of T1D, and to increase the understanding of the pathogenetic factors involved in the development of T1D.