NATURAL HISTORY STUDY OF THE DEVELOPMENT OF TYPE 1 DIABETES TRIALNET

1 型糖尿病试验网开发的自然史研究

• 批准号: 7378526
• 负责人: JAN S. ULBRECHT
• 金额: $ 0.95万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378526
• 关键词: NATURAL; HISTORY; STUDY; DEVELOPMENT; TYPE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of the TrialNet Natural History Study of the Development of Type 1 Diabetes (T1D) are to both gain information about the pathogenesis and natural history of T1D and to facilitate the recruitment and assessment of individuals who might qualify for T1D prevention trials. Importantly, the information obtained from this study will serve to enable the development and implementation of prevention trials. The overall objective of this study is to perform baseline and repeat assessments over time of the metabolic and immunologic status of individuals at risk for T1D in order to characterize their risk for developing T1D, to describe the pathogenetic evolution of T1D, and to increase the understanding of the pathogenetic factors involved in the development of T1D.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。1型糖尿病（T1D）发展的TrialNet自然历史研究的目标是获得有关T1D发病机制和自然历史的信息，并促进招募和评估可能符合T1D预防试验资格的个体。重要的是，从这项研究中获得的信息将有助于开展和实施预防试验。本研究的总体目标是对T1D风险个体的代谢和免疫状态进行基线和长期重复评估，以表征其发展为T1D的风险，描述T1D的发病演变，并增加对T1D发展的发病因素的理解。