IMPAIRED REASONING & SOCIAL JUDGE IN FRONTOTEMPORAL LOBAR DEGEN IN ALS

推理能力受损

• 批准号: 7951268
• 负责人: CLAIRE FLAHERTY-CRAIG
• 金额: $ 0.14万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951268
• 关键词: Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Frontotemporal Lobar Degenerations; Funding; Grant; Incidence; Institution; Judgment; Letters; Lobar; Mediating; Monitor; Patients; Problem Solving; Process; Research; Research Personnel; Resources; Retrieval; Source; United States National Institutes of Health; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Frontotemporal lobar degeneration (FTLD) in patients with ALS appears to be common, with an incidence approaching 50 percent. Many studies have identified impaired frontal cortical mediated letter fluency as a marker of FTLD in ALS, considering impaired letter fluency to be the result of an acquired deficit in self-monitoring during the word retrieval process (Abrahams et al., 2000). However, few studies had examined the relationship between ALS and self-monitoring on a more comprehensive level. We hypothesized that the FTLD associated with ALS would result in an acquired deficiency in social judgment, due to a diminished capacity for self-monitoring during the process of verbal problem solving.

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