IMPAIRED REASONING & SOCIAL JUDGE IN FRONTOTEMPORAL LOBAR DEGEN IN ALS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 ALS患者的额颞叶变性（FTLD）似乎很常见，发病率接近50%。 许多研究已经将受损的额叶皮层介导的字母流畅性确定为ALS中FTLD的标志，认为受损的字母流畅性是单词检索过程中自我监控的获得性缺陷的结果（Abrahams等人，2000年）。 然而，很少有研究在更全面的层面上研究ALS和自我监控之间的关系。 我们假设与ALS相关的FTLD会导致社会判断的后天缺陷，这是由于在语言问题解决过程中自我监控能力的减弱。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Frontotemporal lobar degeneration (FTLD) in patients with ALS appears to be common, with an incidence approaching 50 percent. Many studies have identified impaired frontal cortical mediated letter fluency as a marker of FTLD in ALS, considering impaired letter fluency to be the result of an acquired deficit in self-monitoring during the word retrieval process (Abrahams et al., 2000). However, few studies had examined the relationship between ALS and self-monitoring on a more comprehensive level. We hypothesized that the FTLD associated with ALS would result in an acquired deficiency in social judgment, due to a diminished capacity for self-monitoring during the process of verbal problem solving.