MAAAI
MAAAI
批准号:
7951448
负责人:
DUANE T. SMOOT
金额:
$0.97万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-03-01 至 2010-02-28
关键词:
AfricanAfrican AmericanCandidate Disease GeneClinical ResearchComplexComputer Retrieval of Information on Scientific Projects DatabaseCrohn&aposs diseaseDiseaseFundingGenesGeneticGrantHaplotypesHereditary DiseaseInflammatory Bowel DiseasesInstitutionNational Institute of Diabetes and Digestive and Kidney DiseasesPatternPhenotypePopulationRecruitment ActivityResearchResearch PersonnelResourcesSiteSourceTestingUlcerative ColitisUnited States National Institutes of HealthUniversitiesVariantcohortgenome wide association study
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Inflammatory bowel disease (IBD), Crohn s disease and ulcerative colitis, is a complex genetic disorder with both genetic and environmental causes. The distribution of disease genes varies by ethnic ancestry. We have developed the largest cohort of African American (AA) IBD cases and ethnically matched controls. We have also analyzed the phenotype of IBD in the AA population and determined that the phenotype pattern is significantly different from that of IBD in the white population. We now propose to enlarge the AA cohort to 800 cases and matched controls by year 5. We will perform a whole genome association study in Year4, to identify IBD genes. We well also recruit an AA IBD replication population to confirm genetic findings from the GWA studies. We will use the larger population to determine the significance of unique African ancestral NOD2 variants, further reduce the IBD5 haplotype, determine the cause of IBD3 linkage and reduce its haplotype and test for association and identify unique African ancestral variants for any candidate genes identified in the white by our NIDDK consortium collaborators. Howard University is one of the sites to perform this study.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Differential Transcription Factor Activation by H. pylor
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批准号:6733126
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项目类别:
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资助金额:$4.86万
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财政年份:2003
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负责人:DUANE T. SMOOT
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依托单位:
HOWARD UNIVERSITY CANCER CENTER/JOHNS HOPKINS CANCER CENTER PARTNERSHIP
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批准号:8144502
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项目类别:
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资助金额:$17.26万
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财政年份:2001
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负责人:DUANE T. SMOOT
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依托单位:
HOWARD UNIVERSITY CANCER CENTER/JOHNS HOPKINS CANCER CENTER PARTNERSHIP
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批准号:7498420
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项目类别:
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资助金额:$153.55万
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财政年份:2001
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负责人:DUANE T. SMOOT
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依托单位:
HOWARD UNIVERSITY CANCER CENTER/JOHNS HOPKINS CANCER CENTER PARTNERSHIP
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批准号:7687007
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项目类别:
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资助金额:$97.17万
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财政年份:2001
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负责人:DUANE T. SMOOT
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依托单位:
HOWARD UNIVERSITY CANCER CENTER/JOHNS HOPKINS CANCER CENTER PARTNERSHIP
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批准号:8150102
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项目类别:
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资助金额:$20.0万
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财政年份:2001
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负责人:DUANE T. SMOOT
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依托单位:
HOWARD UNIVERSITY CANCER CENTER/JOHNS HOPKINS CANCER CENTER PARTNERSHIP
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批准号:7931026
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项目类别:
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资助金额:$125.9万
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财政年份:2001
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负责人:DUANE T. SMOOT
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依托单位:
DIFFERENTIAL TRANSCRIPTION FACTOR ACTIVATION BY H PYLORI
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批准号:6024234
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项目类别:
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资助金额:$6.61万
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财政年份:1999
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负责人:DUANE T. SMOOT
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依托单位:
EFFECTS OF DIETARY POLYUNSATURATED FAT ON HELICOBACTER PYLORI
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批准号:6310016
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项目类别:
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资助金额:$20.62万
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财政年份:1999
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负责人:DUANE T. SMOOT
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依托单位:
DIFFERENTIAL TRANSCRIPTION FACTOR ACTIVATION BY H PYLORI
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批准号:6024392
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项目类别:
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资助金额:$4.82万
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财政年份:1998
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负责人:DUANE T. SMOOT
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依托单位:
EFFECTS OF DIETARY POLYUNSATURATED FAT ON HELICOBACTER PYLORI
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批准号:6265913
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项目类别:
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资助金额:$20.62万
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财政年份:1998
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负责人:DUANE T. SMOOT
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依托单位:
DIFFERENTIAL TRANSCRIPTION FACTOR ACTIVATION BY H PYLORI
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批准号:2906176
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项目类别:
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资助金额:$25.49万
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财政年份:1997
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负责人:DUANE T. SMOOT
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依托单位:
Differential Transcription Factor Activation by H. pylor
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批准号:6732630
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项目类别:
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资助金额:$25.21万
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财政年份:1997
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负责人:DUANE T. SMOOT
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依托单位:
Differential Transcription Factor Activation by H. pylor
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批准号:6881069
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项目类别:
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资助金额:$25.21万
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财政年份:1997
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负责人:DUANE T. SMOOT
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依托单位:
DIFFERENTIAL TRANSCRIPTION FACTOR ACTIVATION BY H PYLORI
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批准号:6381097
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项目类别:
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资助金额:$26.11万
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财政年份:1997
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负责人:DUANE T. SMOOT
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依托单位:
Differential Transcription Factor Activation by H. pylor
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批准号:6800297
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项目类别:
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资助金额:$0.46万
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财政年份:1997
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负责人:DUANE T. SMOOT
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依托单位:
Differential Transcription Factor Activation by H. pylor
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批准号:6579774
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项目类别:
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资助金额:$25.2万
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财政年份:1997
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负责人:DUANE T. SMOOT
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依托单位:
DIFFERENTIAL TRANSCRIPTION FACTOR ACTIVATION BY H PYLORI
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批准号:6346641
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项目类别:
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资助金额:$6.8万
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财政年份:1997
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负责人:DUANE T. SMOOT
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依托单位:
Differential Transcription Factor Activation by H. pylor
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批准号:6878252
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项目类别:
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资助金额:$3.21万
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财政年份:1997
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负责人:DUANE T. SMOOT
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依托单位:
Differential Transcription Factor Activation by H. pylor
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批准号:7035747
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项目类别:
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资助金额:$24.73万
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财政年份:1997
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负责人:DUANE T. SMOOT
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依托单位:
DIFFERENTIAL TRANSCRIPTION FACTOR ACTIVATION BY H PYLORI
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批准号:2796619
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项目类别:
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资助金额:$27.32万
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财政年份:1997
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负责人:DUANE T. SMOOT
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依托单位:
海外基金