MAAAI

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 炎症性肠病IBD，克罗恩病和溃疡性结肠炎，是一种复杂的遗传性疾病，遗传和环境的原因。疾病基因的分布因种族血统而异。我们已经开发了最大的非裔美国人AA IBD病例和种族匹配的对照组。我们还分析了AA人群中IBD的表型，并确定其表型模式与白色人群中IBD的表型模式显著不同。我们现在建议到第5年将AA队列扩大到800例病例和匹配对照。我们将在第四年进行全基因组关联研究，以确定IBD基因。我们还招募了AA IBD复制人群，以确认GWA研究的遗传发现。我们将使用更大的人群来确定独特的非洲祖先NOD 2变异的意义，进一步减少IBD 5单倍型，确定IBD 3连锁的原因并减少其单倍型，并测试相关性，并确定独特的非洲祖先变异的任何候选基因中确定的白色由我们的NIDDK联盟合作者。霍华德大学是进行本研究的研究中心之一。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Inflammatory bowel disease (IBD), Crohn s disease and ulcerative colitis, is a complex genetic disorder with both genetic and environmental causes. The distribution of disease genes varies by ethnic ancestry. We have developed the largest cohort of African American (AA) IBD cases and ethnically matched controls. We have also analyzed the phenotype of IBD in the AA population and determined that the phenotype pattern is significantly different from that of IBD in the white population. We now propose to enlarge the AA cohort to 800 cases and matched controls by year 5. We will perform a whole genome association study in Year4, to identify IBD genes. We well also recruit an AA IBD replication population to confirm genetic findings from the GWA studies. We will use the larger population to determine the significance of unique African ancestral NOD2 variants, further reduce the IBD5 haplotype, determine the cause of IBD3 linkage and reduce its haplotype and test for association and identify unique African ancestral variants for any candidate genes identified in the white by our NIDDK consortium collaborators. Howard University is one of the sites to perform this study.