MAAAI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 炎症性肠病，克罗恩S病和溃疡性结肠炎，是一种复杂的遗传性疾病，有遗传和环境两方面的原因。疾病基因的分布因种族血统而异。我们发展了最大的非裔美国人IBD病例和种族匹配的对照。我们还分析了AA人群中IBD的表型，并确定了其表型模式与白人人群中IBD的表型模式显著不同。我们现在建议到第五年将AA队列扩大到800例和匹配的对照组。我们将在第四年进行全基因组关联研究，以确定IBD基因。我们还招募了AA IBD复制人群，以确认GWA研究的遗传发现。我们将使用更大的群体来确定独特的非洲祖先NOD2变异的重要性，进一步减少IBD5单倍型，确定IBD3连锁的原因并减少其单倍型，并测试关联性，并为我们的NIDDK财团合作者在白色中发现的任何候选基因识别独特的非洲祖先变异。霍华德大学是进行这项研究的地点之一。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Inflammatory bowel disease (IBD), Crohn s disease and ulcerative colitis, is a complex genetic disorder with both genetic and environmental causes. The distribution of disease genes varies by ethnic ancestry. We have developed the largest cohort of African American (AA) IBD cases and ethnically matched controls. We have also analyzed the phenotype of IBD in the AA population and determined that the phenotype pattern is significantly different from that of IBD in the white population. We now propose to enlarge the AA cohort to 800 cases and matched controls by year 5. We will perform a whole genome association study in Year4, to identify IBD genes. We well also recruit an AA IBD replication population to confirm genetic findings from the GWA studies. We will use the larger population to determine the significance of unique African ancestral NOD2 variants, further reduce the IBD5 haplotype, determine the cause of IBD3 linkage and reduce its haplotype and test for association and identify unique African ancestral variants for any candidate genes identified in the white by our NIDDK consortium collaborators. Howard University is one of the sites to perform this study.