EFFECTS OF YOGA ON INSULIN SENSITIVITY AND INDICES OF CARDIOVASCULAR RISK

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 心血管疾病(CVD)是女性死亡的主要原因，随着更年期的到来，风险急剧上升。越来越多的证据表明，瑜伽练习可能会为减少心血管疾病的风险因素提供一种安全和成本效益高的策略。然而，西方人群中严格的研究很少，而且瑜伽对健康绝经后女性心血管疾病风险的影响还没有研究。这项研究将调查为期8周的温和瑜伽对50-70岁健康绝经后女性胰岛素抵抗和心血管风险相关指标的影响。60名符合条件、久坐不动的志愿者将被随机分为瑜伽组或对照组(日常护理)。在8周的治疗前后，将采集空腹血样，并测量心血管疾病风险的特定标记物。这将包括测量胰岛素抵抗和葡萄糖耐量，以及血脂水平；心率、血压、心率变异性；身体尺寸和组成，以及其他相关的心血管疾病风险的生理和心理指标。这项探索性的先导性研究可能会为瑜伽在预防绝经后女性心血管疾病方面的潜在效用提供重要信息，绝经后女性是患这种疾病和其他相关严重慢性病风险增加的人群。这项研究的结果还将提供初步数据，以支持一项更大规模的临床试验，调查瑜伽练习对绝经后女性心血管疾病风险指标的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Risk for cardiovascular disease (CVD), the leading cause of death in women, rises sharply with menopause. There is growing evidence that the practice of yoga may offer a safe and cost-effective strategy for reducing risk factors for CVD. However, rigorous studies in Western populations are few and the effects of yoga on CVD risk profiles in healthy postmenopausal women have not been studied. This study will investigate the effects of a gentle 8-week yoga program on insulin resistance and related indices of cardiovascular risk in healthy postmenopausal women aged 50-70. Sixty eligible, sedentary volunteers will be randomized into yoga or control (usual care) groups. Before and after the 8-week treatment period, fasting blood samples will be collected, and specific markers of CVD risk will be measured. These will include measures of insulin resistance and glucose tolerance, as well as lipid profiles; heart rate, blood pressure, heart rate variability; body size and composition, and other related physiological and psychological markers of CVD risk. This exploratory pilot study may yield important information on the potential utility of yoga in preventing CVD in postmenopausal women, a population at increased risk for this and other related serious chronic disorders. Findings of this study will also provide preliminary data to support a larger clinical trial investigating the influence of yoga practice on indices of CVD risk in women post-menopause.