THALASSEMIA DATA AND BLOOD SPECIMEN COLLECTION SYSTEM

地中海贫血数据和血液样本采集系统

• 批准号: 7380732
• 负责人: ELLIS J NEUFELD
• 金额: $ 1.11万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380732
• 关键词: THALASSEMIA; DATA; BLOOD; SPECIMEN; COLLECTION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rationale: The number of persons with thalassemia major in the US is not known, but is estimated to be about 600 - 1000. Six large thalassemia treatment centers located in Boston, MA, Chicago, IL, Philadelphia, PA, New York, NY, Los Angeles and Oakland, CA provide care to about 400 people with thalassemia. In October 2002, CDC begain a 5yr cooperative agreement with these six thalassemia treatment centers to establish a blood safety monitoring system and to assist with the analysis of a uniform set of clinical data routinely collected on these individuals. Aim I: Free testing of blood speciments collected on a regular basis from persons receiving care in these thalassemia treatment centers for the presence of blood borne pathogens with be offered by CDC to assist the treatment centers in monitoring related infections. After testing, the remainder of each serum specimen will be used by the CDC to establish a serum bank for possible future use in evaluating the safety of blood products used by these persons. Aim II: Information from this system, including demographic and epidemiologic data on the participating subjects, will be used by the Hematologic Diseases Branch of CDC to assess the safety of the blood supply and to develop and monitor the effectiveness of interventions designed to address our mandate from congress, which is to reduce or prevent the complications of thalassemia. It is anticipated that the Thalassemia Data and BloodSpecimen COllection System will continue into the foreseeable future as the CDC continues its prevention activities for this population.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。理论基础：美国重型地中海贫血患者的人数尚不清楚，但估计约为600-1000人。位于马萨诸塞州波士顿、伊利诺伊州芝加哥、宾夕法尼亚州费城、纽约、纽约、洛杉矶和加利福尼亚州奥克兰的六个大型地中海贫血治疗中心为大约400名地中海贫血患者提供治疗。2002年10月，CDC开始与这六个地中海贫血治疗中心达成为期5年的合作协议，以建立一个血液安全监测系统，并协助分析一套关于这些人的常规收集的统一临床数据。目的一：对这些地中海贫血治疗中心的护理人员定期采集的血液样本进行免费检测，以确定是否存在血液传播的病原体，并由疾病预防控制中心提供，以协助治疗中心监测相关感染。检测后，每个血清样本的剩余部分将被疾病预防控制中心用来建立一个血清库，供将来评估这些人使用的血液产品的安全性时使用。目的II：来自该系统的信息，包括参与对象的人口学和流行病学数据，将被疾控中心血液病分部用来评估血液供应的安全性，并开发和监测旨在满足国会授权的干预措施的有效性，即减少或预防地中海贫血的并发症。随着疾控中心继续为这一人群开展预防活动，预计地中海贫血数据和血型特征收集系统将持续到可预见的未来。