PRE/POST-SYNAPTIC SPINAL MECHANISMS W LOCAL/DISTANT MANUAL THERAPY INTERVENTIONS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 手动治疗，如关节松动/操作已被证明会影响运动神经元池兴奋性。本项目的总体目标是确定局部和远程动员/操作干预对存在股四头肌抑制的个体的股四头肌突触前和突触后抑制的影响。这将是一项双盲随机对照试验，其中75名受试者将被随机分配接受四种手动治疗干预之一或不接受治疗，并将在四头肌肌肉激活的测量方面进行比较。结果将是测量峰-峰H反射、配对反射抑制和随时间推移的复发性抑制 这项研究将有助于阐明在肌肉无力患者中进行手动治疗干预后改善肌肉功能的机制。将确定在受影响身体部位附近或下背部/骨盆区域进行治疗的具体影响。这些信息将有助于开发手动治疗的最佳使用与肌肉无力继发于受伤的人。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Manual therapies such as joint mobilization/manipulation have been shown to affect motoneuron pool excitability. The overall aim of this project is to determine the effect of local and distant mobilization/manipulation interventions on pre-synaptic and post-synaptic inhibition of the quadriceps muscle in individuals with existing quadriceps inhibition. This will be a double-blinded randomized controlled trial in which 75 subjects will be randomly assigned to receive one of four manual therapy interventions or no treatment and will be compared on measures of quadriceps muscle activation. Outcomes will be the measurements of peak-to-peak H-reflex, paired reflex depression, and recurrent inhibition over time This study will help elucidate the mechanisms responsible for improved muscle function following manual therapy interventions in people with muscle weakness. The specific effects from performing the treatment near the affected body part or at the lower back/pelvic region will be determined. This information will help develop optimal use of manual therapy treatments in people with muscle weakness secondary to injury.