PRE/POST-SYNAPTIC SPINAL MECHANISMS W LOCAL/DISTANT MANUAL THERAPY INTERVENTIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 手法治疗，如关节松动/手法，已被证明影响运动神经元池的兴奋性。本项目的总体目标是确定局部和远程活动/手法干预对存在股四头肌抑制的个体的突触前和突触后抑制股四头肌的影响。这将是一项双盲随机对照试验，75名受试者将被随机分配到四种手动治疗干预措施中的一种，或不接受治疗，并将在股四头肌肌肉激活的指标上进行比较。结果将是测量从峰到峰的H反射、成对反射抑制和随时间推移的反复抑制 这项研究将有助于阐明手动治疗干预后肌肉无力患者肌肉功能改善的机制。将确定在受影响的身体部位附近或在下背部/骨盆区域进行治疗的具体效果。这些信息将有助于开发对继发于损伤的肌肉无力的人进行最佳手动治疗的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Manual therapies such as joint mobilization/manipulation have been shown to affect motoneuron pool excitability. The overall aim of this project is to determine the effect of local and distant mobilization/manipulation interventions on pre-synaptic and post-synaptic inhibition of the quadriceps muscle in individuals with existing quadriceps inhibition. This will be a double-blinded randomized controlled trial in which 75 subjects will be randomly assigned to receive one of four manual therapy interventions or no treatment and will be compared on measures of quadriceps muscle activation. Outcomes will be the measurements of peak-to-peak H-reflex, paired reflex depression, and recurrent inhibition over time This study will help elucidate the mechanisms responsible for improved muscle function following manual therapy interventions in people with muscle weakness. The specific effects from performing the treatment near the affected body part or at the lower back/pelvic region will be determined. This information will help develop optimal use of manual therapy treatments in people with muscle weakness secondary to injury.