HYPNOTICS IN THE TREATMENT OF PSYCHIATRIC DISORDERS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 慢性失眠是重度抑郁发作（MDE）期间最常见的症状之一，失眠症状独立预测生活质量（QOL）差，自杀风险增加和MDE复发风险增加。相比之下，初步证据表明，治疗MDE期间的失眠减少了白天的症状负担，提高了生活质量。催眠药物（安眠药）比其他任何疾病都更常用于精神疾病，这并不奇怪，因为许多最新的抗抑郁药几乎没有或根本没有内在的睡眠诱导作用，可能需要沿着抗抑郁药一起开催眠药。然而，人们对最常用的抗抑郁药和催眠药联合使用的疗效和安全性知之甚少。该探索性/开发补助金（R34机制）将实施与MDE相关的失眠治疗，将支持拟定目标结局的数据收集方法的开发，将测试招募和保留参与者的可行性，并将提供在失眠抑郁患者中将催眠药物添加到抗抑郁药的效应量估计。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic insomnia is among the most common symptoms during a major depressive episode (MDE), and the symptom of insomnia independently predicts poor quality of life (QOL), increased risk of suicide, and increased risk for recurrence of MDE. In contrast, preliminary evidence suggests that treatment of insomnia during MDE reduces the daytime symptom burden and improves QOL. Hypnotic medications (sleeping pills) are prescribed more commonly for psychiatric problems than for any other disorder, and this is not surprising since many of the newest antidepressants have little or no intrinsic sleep-inducing effect and may require that a hypnotic be prescribed along with the antidepressant. However, little is known about the efficacy and safety of combining the most commonly used antidepressant and hypnotic medications. This exploratory/development grant (R34 mechanism) will operationalize treatment of insomnia associated with MDE, will support the development of data-gathering methods for the proposed outcomes of interest, shall test the feasibility of recruiting and retaining participants, and shall provide estimates of effect sizes for adding a hypnotic medication to an antidepressant in depressed patients with insomnia.