HYPNOTICS IN THE TREATMENT OF PSYCHIATRIC DISORDERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 慢性失眠是严重抑郁发作(MDE)期间最常见的症状之一，失眠症状独立地预示着生活质量(QOL)差、自杀风险增加以及MDE复发风险增加。相比之下，初步证据表明，在MDE期间治疗失眠可以减少白天的症状负担，提高生活质量。催眠药(安眠药)比其他任何疾病更常用于治疗精神问题，这并不令人惊讶，因为许多最新的抗抑郁药几乎没有或根本没有内在的睡眠诱导作用，可能需要在服用抗抑郁药的同时开催眠药。然而，人们对联合使用最常用的抗抑郁药和催眠药的有效性和安全性知之甚少。这一探索性/发展性赠款(R34机制)将用于MDE相关失眠的治疗，将支持为感兴趣的拟议结果开发数据收集方法，应测试招募和留住参与者的可行性，并应提供对失眠抑郁患者在抗抑郁药中添加催眠药的效果大小的估计。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic insomnia is among the most common symptoms during a major depressive episode (MDE), and the symptom of insomnia independently predicts poor quality of life (QOL), increased risk of suicide, and increased risk for recurrence of MDE. In contrast, preliminary evidence suggests that treatment of insomnia during MDE reduces the daytime symptom burden and improves QOL. Hypnotic medications (sleeping pills) are prescribed more commonly for psychiatric problems than for any other disorder, and this is not surprising since many of the newest antidepressants have little or no intrinsic sleep-inducing effect and may require that a hypnotic be prescribed along with the antidepressant. However, little is known about the efficacy and safety of combining the most commonly used antidepressant and hypnotic medications. This exploratory/development grant (R34 mechanism) will operationalize treatment of insomnia associated with MDE, will support the development of data-gathering methods for the proposed outcomes of interest, shall test the feasibility of recruiting and retaining participants, and shall provide estimates of effect sizes for adding a hypnotic medication to an antidepressant in depressed patients with insomnia.