LAB TRIALS TO DEVELOP MEDICATIONS FOR COCAINE DEPENDENCE--STUDY 1

开发治疗可卡因依赖药物的实验室试验——研究 1

• 批准号: 7951479
• 负责人: Bankole A Johnson
• 金额: $ 43.87万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951479
• 关键词: Acute; Affect; Arts; Behavioral; Clinical Research; Clinical Trials; Cocaine; Cocaine Abuse; Cocaine Dependence; Cognition; Computer Retrieval of Information on Scientific Projects Database; Crossover Design; Double-Blind Method; Effectiveness; Equilibrium; Fatigue; Female; Funding; Grant; Human; Individual; Institution; Laboratory Study; Mediating; Moods; Pharmaceutical Preparations; Physiological; Placebo Control; Positioning Attribute; Research; Research Personnel; Resources; Rewards; Safety; Solid; Source; Techniques; Testing; United States National Institutes of Health; base; male; pyranose; research study; response; topiramate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Topiramate, a substituted fructo-pyranose derivative, is a promising agent for the treatment of cocaine dependence, presumably because by reducing its rewarding affects associated with abuse liability. We propose an experiment using state-of-the-art human abuse liability assessment techniques to examine the subjective, behavioral, and physiological effects of cocaine both alone and in combination with topiramate. The study will be double-blind and placebo-controlled using a balanced (for sequence and position) cross-over design in male and female non treatment-seeking cocaine abusers (total N = 24). The experiment will test the hypothesis that chronically-administered topiramate will significantly reduces acute cocaine-mediated changes in subjective mood and other abuse liability assessments. As a secondary objective of this experiment, we will characterize cocaine's effects on cognition and physiological response in non-fatigued subjects during drug-taking, and determine if, and by how much, these effects are altered by topiramate. In summary, this experiment provides a proof-of-concept analysis of topiramate's ability to reduce cocaine's abuse potential. The results of this human laboratory study should provide a solid basis for planning clinical trials examining the safety and effectiveness of topiramate for the treatment of cocaine-dependent individuals.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 托吡酯是一种取代的果酸丙糖衍生物，是可卡因依赖性治疗的有前途的药物，大概是因为减少与滥用责任相关的奖励影响。我们提出了一个使用最先进的人类虐待责任评估技术的实验，以单独并与托托乳酸酯结合使用可卡因的主观，行为和生理影响。这项研究将使用男性和女性非寻求可卡因施虐者（总n = 24）中的平衡（用于序列和位置）跨界设计进行双盲和安慰剂对照。该实验将检验以下假设：慢性化托吡酯将大大减少急性可卡因介导的主观情绪和其他虐待责任评估的变化。作为该实验的次要目标，我们将表征可卡因对吸毒期间非抑制受试者的认知和生理反应的影响，并确定托吡酯是否会改变这些作用，并通过多少影响。 总而言之，该实验对托吡酯降低可卡因滥用潜力的能力进行了概念验证分析。 这项人类实验室研究的结果应为计划临床试验提供可靠的基础，以检查托吡酯对可卡因依赖性个体的治疗的安全性和有效性。