FUNCTIONAL MRI OF COGNITIVE AND EMOTIONAL ABNORMALITIES IN PATIENTS WITH LUPUS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项研究的目的是了解更多关于狼疮如何影响大脑的信息。 所有狼疮患者都有自身抗体。 抗NR 2抗体是一种自身抗体，在小鼠模型中导致海马和杏仁核中的神经元死亡。 我们将使用大脑功能性磁共振成像和计算机测试，看看是否有抗NR 2抗体的狼疮患者比没有抗体的人经历了更多的损害。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research is to find out more about how lupus affects the brain. All people with lupus have autoantibodies. The anti-NR2 antibody is an autoantibody causes death of neurons in the hippocampus and amygdala in mouse models. We will be using functional magnetic resonance Imaging of the brain and a computerized test to see if people with lupus who have the anti-NR2 antibody have experienced more damage than those without the antibody.