FUNCTIONAL MRI OF COGNITIVE AND EMOTIONAL ABNORMALITIES IN PATIENTS WITH LUPUS

狼疮患者认知和情绪异常的功能 MRI

• 批准号: 8167246
• 负责人: MEGGAN MACKAY
• 金额: $ 0.93万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167246
• 关键词: Affect; Amygdaloid structure; Antibodies; Autoantibodies; Brain; Cause of Death; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Emotional; Functional Magnetic Resonance Imaging; Funding; Grant; Hippocampus (Brain); Institution; Lupus; Neurons; Patients; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; computerized; experience; mouse model

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research is to find out more about how lupus affects the brain. All people with lupus have autoantibodies. The anti-NR2 antibody is an autoantibody causes death of neurons in the hippocampus and amygdala in mouse models. We will be using functional magnetic resonance imaging of the brain and a computerized test to see if people with lupus who have the anti-NR2 antibody have experienced more damage than those without the antibody.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的目的是了解更多关于狼疮如何影响大脑的信息。 所有狼疮患者都有自身抗体。 抗NR 2抗体是一种自身抗体，在小鼠模型中导致海马和杏仁核中的神经元死亡。 我们将使用脑功能磁共振成像和计算机测试来观察是否有抗NR 2抗体的狼疮患者比没有抗体的患者遭受更多的损害。