LOW LEUCINE DIET STUDY

低亮氨酸饮食研究

• 批准号: 7951335
• 负责人: DOUGLAS R. CAVENER
• 金额: $ 11.19万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951335
• 关键词: Adipose tissue; Applications Grants; Body Composition; Caloric Restriction; Carbohydrates; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Diet; Dual-Energy X-Ray Absorptiometry; Essential Amino Acids; Fasting; Fatty acid glycerol esters; Funding; Goals; Grant; Health; Hepatic; Human; Individual; Institution; Insulin; Leucine; Metabolic; Mus; Overweight; Pilot Projects; Research; Research Personnel; Resources; Rodent; Serum; Source; Testing; United States National Institutes of Health; Visceral; base; novel; obesity treatment; research study; response; treatment duration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent studies in mice have shown that eliminating dietary leucine in combination with caloric restriction results in rapid loss of visceral fat stores within seventeen days, without negative health effects. The reduction in visceral fat is correlated with reduced hepatic fat synthesis and serum insulin levels. Thus elimination of dietary leucine mimics a fasting response despite the presence of normal levels of fat and carbohydrates in the test diet. Based upon metabolic similarities between rodent and humans, we hypothesize that a low leucine (LowLEU) diet will stimulate a rapid loss of adipose stores in humans. We propose to conduct a human dietary experiment to test this hypothesis. The goal of this research is develop a novel, safe, and efficacious dietary regime for the rapid loss of excess fat stores. The specific aims of the study will be to: 1) determine if a low leucine diet in combination with moderate caloric restriction will result in rapid loss of excess adipose stores in overweight (BMI= 25-30) individuals; 2) determine if a low leucine diet is tolerated by test subjects; and 3) determine if a low leucine diet is safe as a short-term diet. The proposed LowLEU diet experiment will be conducted over 14 days and will entail 48 test subjects half of which will be administered the LowLEU diet (7% RDA) and half administered the identical diet but with normal leucine levels. Body composition and metabolic parameters will be assessed before and after the 14 day treatment period. We expect to see a rapid reduction in adipose stores as revealed by DXA body composition and BMI analysis. This is a pilot project for which we hope to use for the basis of grant proposal to the NIH to examine the impact of altering dietary essential amino acids in the treatment of obesity and diabetes.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 最近对小鼠的研究表明，消除饮食中的亮氨酸与热量限制相结合，可以在17天内快速减少内脏脂肪储存，而不会对健康产生负面影响。内脏脂肪的减少与肝脏脂肪合成和血清胰岛素水平的降低相关。因此，尽管测试饮食中存在正常水平的脂肪和碳水化合物，但饮食亮氨酸的消除模拟禁食反应。基于啮齿动物和人类之间的代谢相似性，我们假设低亮氨酸（LowLEU）饮食将刺激人类脂肪储存的快速损失。我们建议进行人类饮食实验来验证这一假设。这项研究的目的是开发一种新的，安全的，有效的饮食制度，快速损失多余的脂肪储存。该研究的具体目的是：1）确定低亮氨酸饮食与适度热量限制的组合是否会导致超重（BMI= 25-30）个体中过量脂肪储存的快速损失; 2）确定测试受试者是否耐受低亮氨酸饮食;和3）确定低亮氨酸饮食作为短期饮食是否安全。 拟议的LowLEU饮食实验将进行14天，将需要48名受试者，其中一半将被给予LowLEU饮食（7% RDA），另一半将被给予相同的饮食，但亮氨酸水平正常。将在14天治疗期前后评估身体组成和代谢参数。我们希望看到DXA身体成分和BMI分析显示的脂肪储存迅速减少。 这是一个试点项目，我们希望以此为基础，向美国国立卫生研究院（NIH）提供资助，以研究改变饮食中必需氨基酸对治疗肥胖和糖尿病的影响。