PEDIATRIC HIV/AIDS COHORT STUDIES: ADOLESCENT MASTER PROTOCOL (AMP)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 强效抗逆转录病毒疗法的出现，使越来越多的婴儿和儿童在围产期感染艾滋病毒后能活到青春期。与此同时，自1993年以来，随着预防母婴传播艾滋病毒的有效手段的发展，美国新感染艾滋病毒的婴儿人数急剧下降。因此，美国最大的围产期HIV感染儿童群体由青春期前和青少年组成。其中一些儿童代表长期缓慢进展者，而另一些儿童则受益于有效的联合抗逆转录病毒疗法。艾滋病毒感染及其治疗对这群自出生以来一直感染艾滋病毒的儿童的生长和发育的影响尚不完全清楚。PHACS AMP方案旨在研究HIV感染对成熟关键过程的影响，如青春期发育，骨生长，脂肪分布以及肝，肾和心血管功能。此外，青少年的行为在坚持药物治疗、治疗失败、病毒耐药性的演变以及艾滋病毒的二次传播（包括将耐药病毒传播给他人）方面发挥着重要作用。这些知识可以构成干预措施的基础，以改善受感染儿童的生活质量。不幸的是，全世界感染艾滋病毒的婴儿、儿童和青少年的人数在资源贫乏的国家和保健水平不断提高的国家都在大幅增加。因此，从这项研究中获得的信息将使全世界越来越多的受感染青年受益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The advent of potent ART has resulted in the survival into adolescence of an increasing proportion of infants and children with perinatal HIV infection. At the same time, the number of newly HIV-infected infants in the U.S. has decreased dramatically since 1993 with the development of effective means to prevent mother-to child transmission of HIV. Thus, the largest group of children with perinatal HIV infection in the U.S. consists of pre- adolescents and adolescents. Some of these children represent long-term slow-progressors, while others have benefited from potent combination ART. The impact of HIV infection and its treatment on the growth and development of this cohort of children who have been living with HIV infection since birth is not fully known. The PHACS AMP protocol is designed to study the effect of HIV infection on key processes of maturation such as pubertal development, bone growth, fat distribution, and hepatic, renal and cardiovascular functions. In addition, behavior in adolescents plays a major role in adherence to medications, treatment failure, evolution of viral resistance, and secondary transmission of HIV, including the transmission of resistant virus, to others. This knowledge can form the basis for interventions to improve the quality of life of infected children. Unfortunately, the number of HIV-infected infants, children and adolescents worldwide is growing substantially in both resource-poor countries and in countries with increasing levels of health care. Thus the information gained from this study will benefit the increasing number of infected youth worldwide.