PEDIATRIC HIV/AIDS COHORT STUDIES: ADOLESCENT MASTER PROTOCOL (AMP)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 有效的抗逆转录病毒疗法的出现导致越来越多的婴儿和儿童感染了围产期艾滋病毒而存活到青春期。与此同时，自1993年以来，随着预防艾滋病毒母婴传播的有效手段的发展，美国新感染艾滋病毒的婴儿数量大幅减少。因此，美国最大的围产期艾滋病毒感染儿童群体是青春期前和青少年。这些孩子中的一些人代表着长期进步缓慢的人，而另一些人则受益于强有力的组合艺术。艾滋病毒感染及其治疗对这群从出生起就感染艾滋病毒的儿童的成长和发育的影响尚不完全清楚。PHACS AMP方案旨在研究HIV感染对青春期发育、骨骼生长、脂肪分布以及肝、肾和心血管功能等关键成熟过程的影响。此外，青少年的行为在坚持药物治疗、治疗失败、病毒抗药性的演变以及艾滋病毒的二次传播(包括将抗药性病毒传播给他人)方面发挥着重要作用。这一知识可构成改善受感染儿童生活质量的干预措施的基础。不幸的是，无论是在资源贫乏的国家，还是在卫生保健水平不断提高的国家，全世界感染艾滋病毒的婴儿、儿童和青少年的数量都在大幅增加。因此，从这项研究中获得的信息将使全世界越来越多的受感染青年受益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The advent of potent ART has resulted in the survival into adolescence of an increasing proportion of infants and children with perinatal HIV infection. At the same time, the number of newly HIV-infected infants in the U.S. has decreased dramatically since 1993 with the development of effective means to prevent mother-to child transmission of HIV. Thus, the largest group of children with perinatal HIV infection in the U.S. consists of pre- adolescents and adolescents. Some of these children represent long-term slow-progressors, while others have benefited from potent combination ART. The impact of HIV infection and its treatment on the growth and development of this cohort of children who have been living with HIV infection since birth is not fully known. The PHACS AMP protocol is designed to study the effect of HIV infection on key processes of maturation such as pubertal development, bone growth, fat distribution, and hepatic, renal and cardiovascular functions. In addition, behavior in adolescents plays a major role in adherence to medications, treatment failure, evolution of viral resistance, and secondary transmission of HIV, including the transmission of resistant virus, to others. This knowledge can form the basis for interventions to improve the quality of life of infected children. Unfortunately, the number of HIV-infected infants, children and adolescents worldwide is growing substantially in both resource-poor countries and in countries with increasing levels of health care. Thus the information gained from this study will benefit the increasing number of infected youth worldwide.