ANALYSIS OF BONE HEALTH IN AFRICAN AMERICAN CHILDREN WITH DISTAL FOREARM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 假设01：对环境概况、人体测量数据和饮食的分析表明，与骨骼健康不良相关的流行病学危险因素与非洲裔美国儿童创伤性前臂骨折显著相关。 这些因素包括与维生素D缺乏相关的因素（有限的阳光照射、缺乏外源性补充剂的母乳喂养史、钙和/或维生素D的饮食摄入不足）和BMI增加。 目的01：将对受试者和对照组进行简短访谈，以获得人口统计学数据、损伤情况和日光暴露量化。 使用GCRC生物营养素研究核心，将获得人体测量和饮食评估并进行分析。 数据将包括身高、体重、体重指数、既往母乳喂养史、补充剂使用情况以及当前钙和维生素D的饮食摄入量。 这一具体目标的目的是确定和比较社会人口/环境概况，人类学。数据和饮食风险因素。 假设02：对维生素D缺乏的生物化学指标的分析将表明，至少有10%的创伤性前臂骨折的非洲裔美国儿童缺乏维生素D。 目标02：使用CNMC实验室和GCRC生物分析-质谱核心实验室，我们将评估各组维生素D缺乏症的生化参数。 这些指标包括羟基维生素D、钙和磷水平。 该特定目标的目的是识别和比较各组中亚临床维生素D缺乏/维生素D不足的存在。 假设03：双能X线骨密度仪测量将证明低骨密度和/或骨矿物质含量与创伤性前臂骨折相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis 01: An analysis of environmental profiles, athropometric data and diet will demonstrate that epidemiological risk factors linked with poor bone health are significantly associated wtih traumatic forearm fractures in African American children. these include factors associated with vitamin D deficiency (limited sun exposure, a history of breast feeding with lack of exogenous supplementation, poor dietary intake of calcium and/or vitamin D), and increased BMI. Aim 01: Subjects and controls will be briefly interviewed to obtain demographic data, circumstances of injury and quantification of sun exposure. Using the GCRC Bionutrition Research Core, anthropometric measurements and dietary assessments will be obtained and analyzed. Data will include height, weight, body mass index, history of prior breastfeeding, use of supplementation, and current dietary intake of calcium and Vitamin D. The goal of this specific aim is to identify and compare sociodemographic/environmental profiles, anthro. data and dietary risk factors in the groups. Hypothesis 02: An analysis of biochecmical indicators of vitamin D deficiency will demonstrate that at least ten percent of African American children with traumatic forearm fractures have deficient levels. Aim 02: Using the CNMC laboratory and the GCRC Bioanalytical-Mass Spectometry Core Laboratory, we will evaluate biochemical parameters of Vitamin D deficiency in each of the groupss. These indicators include hydroxyvitamin D, calcium and phosphorous levels. The goal of this specific aim is to identify and compare the presence of subclinical vitamin D deficiency/Vitamin D insufficiency in each of the groups. Hypothesis 03: Dual energy x-ray absorptiometry measurements will demonstrate that low bone density and/or bone mineral content is associated with traumatic forearm fractures.