ANALYSIS OF BONE HEALTH IN AFRICAN AMERICAN CHILDREN WITH DISTAL FOREARM

非洲裔美国儿童前臂远端骨骼健康分析

• 批准号: 8167337
• 负责人: Leticia Ryan
• 金额: $ 2.1万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-20 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167337
• 关键词: African American; Biochemical; Body mass index; Bone Density; Bone Mineral Contents; Breast Feeding; Calcium; Child; Computer Retrieval of Information on Scientific Projects Database; Data; Diet; Dietary Assessment; Dietary intake; Distal; Epidemiology; Forearm; Forearm Fracture; Funding; Goals; Grant; Height; Injury; Institution; Interview; Laboratories; Link; Measurement; Phosphorous; Recording of previous events; Research; Research Personnel; Resources; Risk Factors; Source; Sun Exposure; Supplementation; United States National Institutes of Health; Vitamin D; Vitamin D Deficiency; Weight; bone health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis 01: An analysis of environmental profiles, athropometric data and diet will demonstrate that epidemiological risk factors linked with poor bone health are significantly associated wtih traumatic forearm fractures in African American children. these include factors associated with vitamin D deficiency (limited sun exposure, a history of breast feeding with lack of exogenous supplementation, poor dietary intake of calcium and/or vitamin D), and increased BMI. Aim 01: Subjects and controls will be briefly interviewed to obtain demographic data, circumstances of injury and quantification of sun exposure. Using the GCRC Bionutrition Research Core, anthropometric measurements and dietary assessments will be obtained and analyzed. Data will include height, weight, body mass index, history of prior breastfeeding, use of supplementation, and current dietary intake of calcium and Vitamin D. The goal of this specific aim is to identify and compare sociodemographic/environmental profiles, anthro. data and dietary risk factors in the groups. Hypothesis 02: An analysis of biochecmical indicators of vitamin D deficiency will demonstrate that at least ten percent of African American children with traumatic forearm fractures have deficient levels. Aim 02: Using the CNMC laboratory and the GCRC Bioanalytical-Mass Spectometry Core Laboratory, we will evaluate biochemical parameters of Vitamin D deficiency in each of the groupss. These indicators include hydroxyvitamin D, calcium and phosphorous levels. The goal of this specific aim is to identify and compare the presence of subclinical vitamin D deficiency/Vitamin D insufficiency in each of the groups. Hypothesis 03: Dual energy x-ray absorptiometry measurements will demonstrate that low bone density and/or bone mineral content is associated with traumatic forearm fractures.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 假设 01：对环境概况、人体测量数据和饮食的分析将证明，与骨骼健康状况不佳相关的流行病学危险因素与非裔美国儿童的外伤性前臂骨折显着相关。 这些因素包括与维生素 D 缺乏相关的因素（阳光照射有限、缺乏外源性补充剂的母乳喂养史、饮食中钙和/或维生素 D 摄入不足）以及体重指数 (BMI) 增加。 目标 01：将对受试者和对照进行简短访谈，以获得人口统计数据、受伤情况和阳光照射的量化。 使用 GCRC 生物营养研究核心，将获得并分析人体测量结果和饮食评估。 数据将包括身高、体重、体重指数、既往母乳喂养史、补充剂的使用情况以及当前钙和维生素 D 的饮食摄入量。这一具体目标的目标是识别和比较社会人口/环境概况、人类。各组数据和饮食危险因素。 假设 02：对维生素 D 缺乏症的生化指标的分析将表明，至少 10% 的患有外伤性前臂骨折的非裔美国儿童存在维生素 D 缺乏症。 目标 02：利用 CNMC 实验室和 GCRC 生物分析-质谱核心实验室，我们将评估各组维生素 D 缺乏的生化参数。 这些指标包括羟基维生素 D、钙和磷的水平。 这一具体目标的目的是确定并比较各组中亚临床维生素 D 缺乏/维生素 D 不足的情况。 假设 03：双能 X 射线骨密度测量将证明低骨密度和/或骨矿物质含量与外伤性前臂骨折有关。