ZN-INDUCED PEPTIDE FOLDING
ZN-INDUCED PEPTIDE FOLDING
批准号:
7955441
负责人:
JEFFERY G SAVEN
金额:
$0.48万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-06-01 至 2010-05-31
关键词:
BindingComputer Retrieval of Information on Scientific Projects DatabaseEventFundingGrantInstitutionKineticsLaboratoriesOpticsPeptidesPositioning AttributeProcessProteinsResearchResearch PersonnelResourcesSourceStagingStructureTertiary Protein StructureUnited States National Institutes of Healthcofactornumb proteinpolypeptide
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The study of the folding mechanism of single domain proteins that lack cofactors has reached an advanced stage wherein the sequence of events along the course of refolding after denaturation begins to be understood. In several cases, it has been even possible to describe in detail the energetics, position, and structure of the folding transition states and/or intermediate states involved. In contrast, there are far fewer studies on cofactor-induced folding kinetics, even though a large number of proteins require cofactors for proper folding and/or function. While the effect of cofactor-binding on the structure and stability may differ for different proteins, many polypeptides can only attain a well-folded structure when associated with their respective cofactors.
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会议论文
FAST KINETICS OF DESIGNED SERPINS
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批准号:7723850
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项目类别:
-
资助金额:$0.26万
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财政年份:2008
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负责人:JEFFERY G SAVEN
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依托单位:
FAST KINETICS OF DESIGNED SERPINS
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批准号:7598449
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项目类别:
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资助金额:$0.4万
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财政年份:2007
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负责人:JEFFERY G SAVEN
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依托单位:
FOLDING DYNAMICS OF COMPUTATIONALLY DESIGNED PROTEINS
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批准号:7373158
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项目类别:
-
资助金额:$0.34万
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财政年份:2006
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负责人:JEFFERY G SAVEN
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依托单位:
FOLDING DYNAMICS OF COMPUTATIONALLY DESIGNED PROTEINS
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批准号:7183308
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项目类别:
-
资助金额:$0.34万
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财政年份:2005
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负责人:JEFFERY G SAVEN
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依托单位:
Computational Studies of Protein Folding and Design
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批准号:7039069
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项目类别:
-
资助金额:$23.72万
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财政年份:2002
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负责人:JEFFERY G SAVEN
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依托单位:
Computational Studies of Protein Folding and Design
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批准号:6624279
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项目类别:
-
资助金额:$24.46万
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财政年份:2002
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负责人:JEFFERY G SAVEN
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依托单位:
Computational Studies of Protein Folding and Design
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批准号:6473349
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项目类别:
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资助金额:$26.85万
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财政年份:2002
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负责人:JEFFERY G SAVEN
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依托单位:
Computational Studies of Protein Folding and Design
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批准号:6710645
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项目类别:
-
资助金额:$24.4万
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财政年份:2002
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负责人:JEFFERY G SAVEN
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依托单位:
Computational Studies of Protein Folding and Design
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批准号:6879222
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项目类别:
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资助金额:$24.35万
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财政年份:2002
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负责人:JEFFERY G SAVEN
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依托单位: