COMPRESSED SENSING APPLICATIONS TO METABOLIC IMAGING
压缩传感在代谢成像中的应用
基本信息
- 批准号:7956995
- 负责人:
- 金额:$ 0.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-01 至 2010-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressBenignBrainBreastChemical Shift ImagingCholineClinicClinicalComputer Retrieval of Information on Scientific Projects DatabaseDataData QualityData SetDisease ProgressionFundingGrantImageInstitutionKnowledgeMRI ScansMagnetic Resonance ImagingMapsMetabolicMetabolismMethodsMonitorNeoplasm MetastasisPatientsResearchResearch PersonnelResourcesScanningSourceTechniquesTechnologyTimeTissuesTreatment EfficacyUnited States National Institutes of Healthbasein vivoreconstructiontumor
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
It is well known that knowledge of metabolite levels in healthy and diseased tissues can provide essential information on disease progression and efficacy of therapy. For instance, metastatic tumors have increased levels of metabolites like choline and lactate compared to benign tumors. 3 dimensional Chemical Shift Imaging (3D-CSI) is an MR-based non-invasive approach used in the clinic to quantify and monitor these metabolites. A major hurdle in routine clinical use of 3D-CSI is the long acquisition time and hence the time spent by the patient in the scanner. Therefore a strong need to address this problem exists to enable clinicians to make routine use of this powerful technology. The proposed project aims to overcome this limitation by the use of compressive sensing, which has been a revolutionary invention in the past few years. This technique has been successfully implemented for MRI and promises to be a new path for reducing acquisition times for MRI scans. We plan to conduct a retrospective analysis of brain and breast CSI data sets in order to compare metabolite maps obtained with conventional k-space reconstruction method to compressive sensing based reconstruction using undersampled data. We hypothesize that by exploiting the sparsity of k-space as well as the spectral data, we may be able to reduce CSI scan times for patients by a factor of 2 without significant reduction in the quality of data.
这个子项目是许多利用
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。列出的机构为
研究中心,而研究中心不一定是研究者所在的机构。
众所周知,健康和患病组织中代谢物水平的知识可以提供关于疾病进展和治疗功效的重要信息。例如,与良性肿瘤相比,转移性肿瘤具有增加的代谢物水平,如胆碱和乳酸。三维化学位移成像(3D-CSI)是一种基于MR的非侵入性方法,用于临床定量和监测这些代谢物。3D-CSI的常规临床使用中的主要障碍是较长的采集时间,因此患者在扫描仪中花费的时间较长。因此,迫切需要解决这个问题,以使临床医生能够常规使用这种强大的技术。该项目旨在通过使用压缩传感来克服这一限制,这在过去几年中已经成为一项革命性的发明。该技术已成功应用于MRI,有望成为减少MRI扫描采集时间的新途径。我们计划对脑和乳腺CSI数据集进行回顾性分析,以便将使用传统k空间重建方法获得的代谢物图谱与使用欠采样数据进行的基于压缩感知的重建进行比较。我们假设,通过利用k空间的稀疏性以及频谱数据,我们可能能够将患者的CSI扫描时间减少2倍,而不会显着降低数据质量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vikram D. Kodibagkar其他文献
Vikram D. Kodibagkar的其他文献
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{{ truncateString('Vikram D. Kodibagkar', 18)}}的其他基金
One-shot morphologic, hemodynamic and metabolic MR imaging of brain tumors
脑肿瘤的一次性形态学、血流动力学和代谢 MR 成像
- 批准号:
10680562 - 财政年份:2021
- 资助金额:
$ 0.89万 - 项目类别:
Optimizing macroencapsulation devices for islet transplantation via magnetic resonance oximetry
通过磁共振血氧测定法优化胰岛移植的宏观封装装置
- 批准号:
10276561 - 财政年份:2021
- 资助金额:
$ 0.89万 - 项目类别:
One-shot morphologic, hemodynamic and metabolic MR imaging of brain tumors
脑肿瘤的一次性形态学、血流动力学和代谢 MR 成像
- 批准号:
10445086 - 财政年份:2021
- 资助金额:
$ 0.89万 - 项目类别:
One-shot morphologic, hemodynamic and metabolic MR imaging of brain tumors
脑肿瘤的一次性形态学、血流动力学和代谢 MR 成像
- 批准号:
10316545 - 财政年份:2021
- 资助金额:
$ 0.89万 - 项目类别:
Optimizing macroencapsulation devices for islet transplantation via magnetic resonance oximetry
通过磁共振血氧测定法优化胰岛移植的宏观封装装置
- 批准号:
10649668 - 财政年份:2021
- 资助金额:
$ 0.89万 - 项目类别:
ADVANCED MR FOR PROBING TUMOR MICROENVIRONMENT
用于探测肿瘤微环境的高级 MR
- 批准号:
8363920 - 财政年份:2011
- 资助金额:
$ 0.89万 - 项目类别:
ADVANCED MR TECHNOLOGIES FOR PROBING THE TUMOR MICROENVIRONMENT
用于探测肿瘤微环境的先进 MR 技术
- 批准号:
8171671 - 财政年份:2010
- 资助金额:
$ 0.89万 - 项目类别:
1H MRI based nanosensors for imaging tumor oxygenation
基于 1H MRI 的纳米传感器用于肿瘤氧合成像
- 批准号:
7753210 - 财政年份:2009
- 资助金额:
$ 0.89万 - 项目类别:
EVALUATION OF THERAPY FOR BREAST CANCER USING PARACEST MRI
使用 Paracest MRI 评估乳腺癌治疗
- 批准号:
7956977 - 财政年份:2009
- 资助金额:
$ 0.89万 - 项目类别:
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