Identifying, validating and exploiting a novel dclk1-positive bipotential lung stem cell

鉴定、验证和利用新型 dclk1 阳性双能肺干细胞

• 批准号: nhmrc : 1066970
• 负责人: Dr Emma Stuart
• 金额: $ 33.38万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-validating-exploiting-stem-cell/455274
• 关键词: Identifying; validating; exploiting; novel; dclk1

The discovery of stem cells has changed our understanding and approach to treating chronic diseases. Unlike other organs, the stem cells that maintain and repair the lung remain poorly characterised. I have recently identified a gene that labels a population of cells which contribute to epithelial repopulation of the lung. This project aims to characterise how this population behaves during lung homeostasis and following lung injury, with a view to translating these findings to the clinic.

干细胞的发现改变了我们对慢性疾病治疗的理解和方法。与其他器官不同，维持和修复肺部的干细胞的特征仍然很差。我最近发现了一种基因，它标记了有助于肺上皮再生的细胞群。该项目旨在描述该人群在肺稳态和肺损伤后的行为特征，以期将这些发现转化为临床。