NEW TECHNIQUE FOR DYNAMIC CONTRAST ENHANCED BREAST MRI

动态对比增强乳腺 MRI 新技术

• 批准号: 7955297
• 负责人: HEE KWON SONG
• 金额: $ 2.23万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955297
• 关键词: Animal Model; Benign; Breast; Color; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Early Diagnosis; Enhancing Lesion; Funding; Grant; Image; Imagery; Imaging Techniques; Institution; Kinetics; Lesion; Magnetic Resonance; Magnetic Resonance Imaging; Malignant - descriptor; Maps; Modeling; Radial; Research; Research Personnel; Resolution; Resources; Series; Source; Techniques; Therapeutic; United States National Institutes of Health; angiogenesis; cancer imaging; human subject; interest; optical imaging; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dynamic contrast MRI is being widely applied to studies of cancer imaging. Applications include characterization of lesions as benign or malignant and assessing therapeutic response. There is particular interest in the use of dynamic contrast enhanced (DCE) MRI for the early detection of response therapies that target angiogenesis in human subjects and animal models. Previously we had developed an interleaved backprojection (or radial) imaging technique that allows acquisition of a series of images with both high temporal and spatial resolutions (dynamic KWIC). More recently we have enhanced lesion visualization and diagnosis by creating color maps that represent various parameters of the contrast-enhancement kinetic model.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 动态对比 MRI 正在广泛应用于癌症成像研究。应用包括 病变的良性或恶性特征并评估治疗反应。有 对使用动态对比增强 (DCE) MRI 进行早期检测特别感兴趣 针对人类受试者和动物模型中的血管生成的反应疗法。以前我们 开发了一种交错反投影（或径向）成像技术，允许采集 一系列具有高时间和空间分辨率的图像（动态 KWIC）。更多的 最近，我们通过创建彩色图来增强病变可视化和诊断 代表对比度增强动力学模型的各种参数。