NEW TECHNIQUE FOR DYNAMIC CONTRAST ENHANCED BREAST MRI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 动态增强MRI在肿瘤成像研究中得到了广泛应用。应用包括 将病变定性为良性或恶性，并评估治疗反应。的确有 特别关注使用动态增强(DCE)MRI来早期检测 针对人类受试者和动物模型血管生成的反应疗法。以前我们有过 开发了一种交错反投影(或径向)成像技术，允许获取 具有高时间和空间分辨率的系列图像(动态KWIC)。最近，我们 通过创建代表各种类型的彩色地图来增强病变可视化和诊断 对比度增强动力学模型的参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dynamic contrast MRI is being widely applied to studies of cancer imaging. Applications include characterization of lesions as benign or malignant and assessing therapeutic response. There is particular interest in the use of dynamic contrast enhanced (DCE) MRI for the early detection of response therapies that target angiogenesis in human subjects and animal models. Previously we had developed an interleaved backprojection (or radial) imaging technique that allows acquisition of a series of images with both high temporal and spatial resolutions (dynamic KWIC). More recently we have enhanced lesion visualization and diagnosis by creating color maps that represent various parameters of the contrast-enhancement kinetic model.