NEW TECHNIQUE FOR DYNAMIC CONTRAST ENHANCED BREAST MRI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 动态对比MRI正广泛应用于肿瘤成像研究。应用包括 将病变表征为良性或恶性并评估治疗反应。有 特别感兴趣的是使用动态对比增强（DCE）MRI早期检测 在人类受试者和动物模型中靶向血管生成的反应疗法。以前我们有 开发了一种交错反投影（或径向）成像技术， 一系列具有高时间和空间分辨率的图像（动态KWIC）。最近我们 通过创建代表各种病变的彩色图， 对比度增强动力学模型的参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dynamic contrast MRI is being widely applied to studies of cancer imaging. Applications include characterization of lesions as benign or malignant and assessing therapeutic response. There is particular interest in the use of dynamic contrast enhanced (DCE) MRI for the early detection of response therapies that target angiogenesis in human subjects and animal models. Previously we had developed an interleaved backprojection (or radial) imaging technique that allows acquisition of a series of images with both high temporal and spatial resolutions (dynamic KWIC). More recently we have enhanced lesion visualization and diagnosis by creating color maps that represent various parameters of the contrast-enhancement kinetic model.