SIRTUIN PROTEIN-HISTON DEACETYLASE STUDY

Sirtuin 蛋白-组蛋白去乙酰化酶研究

基本信息

  • 批准号:
    7954658
  • 负责人:
  • 金额:
    $ 0.15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-03-01 至 2010-02-28
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The role of this study is to understand how reversible protein acetylation reactions that regulate biological pathways and chromatin function (epigenetics), are linked to metabolic networks. We are focused on elucidating the mechanisms by which the Sir2 family of protein/histone deacetylases (sirtuins), perform their biological functions. Sirtuins have been implicated in organism longevity, neuronal protection, glucose homeostasis, apoptosis, fatty-acid metabolism and transcriptional control. Although considerable genetic evidence suggests that sirtuins are master regulators of metabolic pathways and epigenetic control of transcription, the molecular and biochemical basis for the varied phenotypes has remained elusive. Sirtuins are NAD+-dependent protein deacetylases and founding members of the class III histone deacetylases (HDACs). The requirement for NAD+, an essential intermediary metabolite in energy homeostasis, and the formation of an unusual product O-acetyl-ADP-ribose are features unique to this class of protein deacetylases. The unusual nature of this reaction and the numerous biological implications have led to the proposed model of sirtuins as central regulations of energy metabolism. We are utilizing Sirtuin KO animals as well as dietary restricted animals to measure the metabolic changes using an unbiased metabolomics to identify changes to metabolic networks through state-of?the art 2D-NMR and mass spectral approaches. This will dovetail with the identification and quantification changes in the acetylproteome as mediated by sirtuin enzymes. This is a highly collaborative study that has been ongoing between the Markley and Denu Lab. This collorbaration has generated previous data sets from the NMRFAM with excellent findings and identification of metabolic differences key to the project. This study is funded by Wisconsin Partnership Fund.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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JOHN M DENU其他文献

JOHN M DENU的其他文献

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{{ truncateString('JOHN M DENU', 18)}}的其他基金

Dynamics and molecular mechanisms linking metabolism and the epigenome
连接代谢和表观基因组的动力学和分子机制
  • 批准号:
    10624003
  • 财政年份:
    2023
  • 资助金额:
    $ 0.15万
  • 项目类别:
Dietary regulation of the hepatic epigenome
肝脏表观基因组的饮食调节
  • 批准号:
    10211950
  • 财政年份:
    2021
  • 资助金额:
    $ 0.15万
  • 项目类别:
Dietary regulation of the hepatic epigenome
肝脏表观基因组的饮食调节
  • 批准号:
    10434846
  • 财政年份:
    2021
  • 资助金额:
    $ 0.15万
  • 项目类别:
Dietary regulation of the hepatic epigenome
肝脏表观基因组的饮食调节
  • 批准号:
    10640272
  • 财政年份:
    2021
  • 资助金额:
    $ 0.15万
  • 项目类别:
Linking mitochondrial variation and lifespan amongst five species of Rodentia
将五种啮齿目动物的线粒体变异与寿命联系起来
  • 批准号:
    9077372
  • 财政年份:
    2016
  • 资助金额:
    $ 0.15万
  • 项目类别:
Role of Sirt3 in Aging and Caloric Restriction
Sirt3 在衰老和热量限制中的作用
  • 批准号:
    8706746
  • 财政年份:
    2011
  • 资助金额:
    $ 0.15万
  • 项目类别:
Role of Sirt3 in Aging and Caloric Restriction
Sirt3 在衰老和热量限制中的作用
  • 批准号:
    8313913
  • 财政年份:
    2011
  • 资助金额:
    $ 0.15万
  • 项目类别:
Role of Sirt3 in Aging and Caloric Restriction
Sirt3 在衰老和热量限制中的作用
  • 批准号:
    8512636
  • 财政年份:
    2011
  • 资助金额:
    $ 0.15万
  • 项目类别:
Role of Sirt3 in Aging and Caloric Restriction
Sirt3 在衰老和热量限制中的作用
  • 批准号:
    8025259
  • 财政年份:
    2011
  • 资助金额:
    $ 0.15万
  • 项目类别:
Reversible Protein Acetylation and Chromatin Function
可逆蛋白质乙酰化和染色质功能
  • 批准号:
    8005210
  • 财政年份:
    2010
  • 资助金额:
    $ 0.15万
  • 项目类别:

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