ANALYSIS OF PROTEIN-PROTEIN INTERACTIONS AND QUASI-EQUIVALENCE IN VIRUS CAPSIDS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 病毒衣壳由一个或几个外壳蛋白亚基的多个拷贝组成。了解衣壳蛋白亚单位在自然环境中(有时是在非自然衣壳环境中)的相互作用程度，对于理解蛋白质构建块与衣壳大小和结构之间的关系将是重要的。此外，亚基的结合和相互作用的相似程度将指向病毒衣壳中的亚基的准等价性。了解蛋白质类型和由此产生的衣壳之间的关系将有助于设计新的和新的衣壳。这个项目的目标是提出量化亚基参与蛋白质-蛋白质相互作用的程度的测量/性质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Viral capsids are composed of multiples copies of one or a few coat protein subunits. Knowledge on the extent of interactions of a capsid protein subunit in native and sometimes in non-native capsid environments will be of importance in understanding the relationship between the protein building block and the capsid size and architecture. Furthermore, the extent of similarity in the bonding and interactions of the subunits would point to the quasi-equivalences of subunits in viral capsids. The knowledge on the relationship between the type of the protein and the resulting capsid would aid in designing new and novel capsids. The objective of this project is to come up with measures/properties that would quantify the extent to which a subunit is involved in the protein-protein interactions.