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SAXS OF DRYSTROPHIN FRAGMENTS

SAXS OF DRYSTROPHIN FRAGMENTS
干肌蛋白片段的 SAXS
批准号:
7954933
负责人:
Nick Menhart
金额:
$0.87万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-01-01 至 2009-12-31

项目摘要

项目成果

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中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. These studies are part of an NIH funded project to determine the domain structure and biophysical properties of the dystrophin rod infamous for its role in Duchenne Muscular Dystrophy. SAXS will be used to determine the structure of various dystrophin rod fragments to determine their shape and flexibility; the aim is to identify rod regions that contain hinges or kinks that disrupt the rod. The fundamental building block of the rod region is the spectrin type repeat, STR, an ~100 amino acid motif present in 24 tandem copies. STRs fold to form zigzag triple a-helical bundle structures with three a-helices in a zigzag arrangement that places the ends of the polypeptide chain at opposite ends of this bundle. Tandem arrangement of STRs thus produces a long, rod shaped molecule. In some regions, adjacent STRs form interacting structures. This has led to the development a of a nested model, in which the three helices of STR bundles are thought of not as (ABC)(ABC)(ABC) , but as A)B(CA)B(CA)B . In this conception, a continuous, long CA helix alternates with a half-size, antiparallel B helix in a two-steps-forward-one-step-back rod, and the exact biophysical domain boundaries are unclear. Although these two models were once rivals, it now seems that both may be applicable in different regions of the rod, possibly leading to very different rod rigidities. However, there is has never been any direct measurement of rod shape or rigidity, which is the aim of our studies.
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Structure of the dystrophin rod in relation to exon boundaries and exon skipping
Structure of the dystrophin rod in relation to exon boundaries and exon skipping
  • 批准号:
    7135690
  • 项目类别:
  • 资助金额:
    $13.44万
  • 财政年份:
    2006
  • 负责人:
    Nick Menhart
  • 依托单位:
Structure of the dystrophin rod in relation to exon boundaries and exon skipping
  • 批准号:
    7462442
  • 项目类别:
  • 资助金额:
    $13.63万
  • 财政年份:
    2006
  • 负责人:
    Nick Menhart
  • 依托单位:
Structure of the dystrophin rod in relation to exon boundaries and exon skipping
  • 批准号:
    7345624
  • 项目类别:
  • 资助金额:
    $13.03万
  • 财政年份:
    2006
  • 负责人:
    Nick Menhart
  • 依托单位:
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  • 批准号:
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  • 项目类别:
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  • 资助金额:
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    2024
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  • 批准号:
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  • 项目类别:
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  • 批准年份:
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