EVOLUTION OF COBALAMIN SYNTHETIC GENES AMONG ENTERIC BACTERIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们正在探索创建和使用人工基因组序列的方法。细菌基因组是使用多个隐马尔可夫模型来建模的，这些模型被用于创建人工基因组。嵌合人工基因组被用来探索现有方法检测横向转移基因的有效性，并用于开发新的、稳健的检测外源基因的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are exploring methods for creation and use of artificial genome sequences. Bacterial genomes are modeled using multiple Hidden Markov Models, and these models are used to create artificial genomes. Chimeric artificial genomes are used to explore the efficacy of exisiting methods for the detection of laterally transferred genes, and for the development of novel, robust methods for detection of alien genes.