EVOLUTION OF COBALAMIN SYNTHETIC GENES AMONG ENTERIC BACTERIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 我们正在探索创造和使用人工基因组序列的方法。细菌基因组使用多个隐马尔可夫模型建模，这些模型用于创建人工基因组。嵌合人工基因组用于探索检测横向转移基因的验证方法的功效，并用于开发用于检测外源基因的新的、稳健的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are exploring methods for creation and use of artificial genome sequences. Bacterial genomes are modeled using multiple Hidden Markov Models, and these models are used to create artificial genomes. Chimeric artificial genomes are used to explore the efficacy of exisiting methods for the detection of laterally transferred genes, and for the development of novel, robust methods for detection of alien genes.