EVOLUTION OF COBALAMIN SYNTHETIC GENES AMONG ENTERIC BACTERIA

肠道细菌中钴胺素合成基因的进化

• 批准号: 7956080
• 负责人: Jeffrey G Lawrence
• 金额: $ 0.08万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956080
• 关键词: Alien; Bacterial Genome; Biomedical Research; Cobalamin; Computer Retrieval of Information on Scientific Projects Database; Detection; Development; Enterobacteriaceae; Evolution; Funding; Gene Transfer; Genes; Genome; Grant; High Performance Computing; Institution; Methods; Modeling; Research; Research Personnel; Resources; Source; Synthetic Genes; United States National Institutes of Health; genome sequencing; markov model; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are exploring methods for creation and use of artificial genome sequences. Bacterial genomes are modeled using multiple Hidden Markov Models, and these models are used to create artificial genomes. Chimeric artificial genomes are used to explore the efficacy of exisiting methods for the detection of laterally transferred genes, and for the development of novel, robust methods for detection of alien genes.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们正在探索创造和使用人工基因组序列的方法。细菌基因组使用多个隐马尔可夫模型建模，这些模型用于创建人工基因组。嵌合人工基因组用于探索检测横向转移基因的验证方法的功效，并用于开发用于检测外源基因的新的、稳健的方法。