ANIMAL MODELS FOR AIDS VACCINE DEVELOPMENT

用于艾滋病疫苗开发的动物模型

• 批准号: 7956066
• 负责人: Ronald C Montelaro
• 金额: $ 0.08万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956066
• 关键词: AIDS vaccine development; Acquired Immunodeficiency Syndrome; Animal Model; Animal Viruses; Antigenic Variation; Biomedical Research; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Disease; Equine Infectious Anemia Virus; Equus caballus; Evolution; Focus Groups; Funding; Genomics; Grant; HIV-1; High Performance Computing; Human; Infection; Institution; Molecular; Monkeys; Nature; Pathogenesis; Population; Property; Research; Research Personnel; Resources; Role; SIV; Source; Staging; System; Tissues; United States National Institutes of Health; Variant; Viral; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The efforts of my research group focus on understanding the molecular mechanisms of lentiviral persistence and pathogenesis using human and animal virus systems, e.g. human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV), and equine infectious anemia virus (EIAV). A major focus of our studies of lentiviral persistence is the characterization of the evolution of viral populations during various stages of disease, the compartmentalization of viral quasispecies to different tissues during persistent infection, and the effects of viral variation on viral immunological properties. These HIV-1 evolution studies are performed in HIV-1 infected subjects that are part of the NIH-funded Multicenter AIDS Cohort Study. In parallel to these HIV-1 studies, experimental infections of monkeys with SIV or horses with EIAV are utilized to examine the nature and role of genomic and antigenic variation in viral persistence and pathogenesis.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我的研究小组的工作重点是利用人类和动物病毒系统，例如人类免疫缺陷病毒1型（HIV-1），猿猴免疫缺陷病毒（SIV）和马传染性贫血病毒（EIAV），了解慢病毒持久性和发病机制的分子机制。我们慢病毒持久性研究的一个主要重点是表征病毒种群在疾病的各个阶段的演变，在持续感染过程中不同组织的病毒准种的区室化，以及病毒变异对病毒免疫学特性的影响。这些HIV-1演变研究是在HIV-1感染受试者中进行的，这些受试者是NIH资助的多中心艾滋病队列研究的一部分。在这些HIV-1研究的同时，利用猴SIV或马EIAV的实验性感染来研究病毒持久性和发病机制中基因组和抗原变异的性质和作用。