ANIMAL MODELS FOR AIDS VACCINE DEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我的研究小组的工作重点是了解黄曲霉毒素的分子机制 使用人和动物病毒系统的慢病毒持久性和致病机制，例如 人类免疫缺陷病毒1型(HIV-1)、猴免疫缺陷病毒(SIV)和 马传染性贫血病毒(EIAV)。慢病毒研究的一个主要焦点 持续性是病毒种群在不同时期进化的特征 疾病的阶段，病毒准种对不同组织的划分 在持续感染期间，以及病毒变异对病毒免疫学的影响 属性。这些HIV-1进化研究是在HIV-1感染的受试者中进行的 是美国国立卫生研究院资助的多中心艾滋病队列研究的一部分。在这些HIV-1病毒的同时 研究，实验感染SIV的猴子或感染EIAV的马被用来 检测基因组和抗原性变异在病毒持久性和 发病机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The efforts of my research group focus on understanding the molecular mechanisms of lentiviral persistence and pathogenesis using human and animal virus systems, e.g. human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV), and equine infectious anemia virus (EIAV). A major focus of our studies of lentiviral persistence is the characterization of the evolution of viral populations during various stages of disease, the compartmentalization of viral quasispecies to different tissues during persistent infection, and the effects of viral variation on viral immunological properties. These HIV-1 evolution studies are performed in HIV-1 infected subjects that are part of the NIH-funded Multicenter AIDS Cohort Study. In parallel to these HIV-1 studies, experimental infections of monkeys with SIV or horses with EIAV are utilized to examine the nature and role of genomic and antigenic variation in viral persistence and pathogenesis.