EVALUATION OF CONFIGURATION PARAMETERS FOR SLIT-SLAT COLLIMATION DESIGN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在这个项目中，我们将使用Geant4核科学程序来模拟不同的准直器设计参数对单光子发射计算机层析成像(SPECT)灵敏度和分辨率的影响。我们以前已经开发了描述几何灵敏度和分辨率(即，没有光子穿透和散射)的解析公式。我们已经开发了初步的侵彻模型，需要使用计算机模拟进行验证。我们目前还没有分散的模型。因此，该项目将利用Geant4来测试穿透和散射模型，以确定它们对使用这种新的准直器的临床发射计算机断层扫描的影响。该项目的次要目标是开发提高重建质量的算法，特别是在4D重建(即门控心脏重建)方面。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project, we will use the Geant4 nuclear-science package to simulate the effects of various collimator design parameters on sensitivity and resolution for single photon emission computed tomography (SPECT). We have previously developed analytic formulas that describe the geometric sensitivity and resolution (i.e., without photon penetration and scatter). We have developed preliminary models for penetration that need to be validated using computer simulation. We do not have at this time models for scatter. Thus, this project will utilize Geant4 to test models of penetration and scatter to determine their impact on clinical emission computed tomography with this new collimator. A secondary goal of this project is to develop algorithms for improved reconstruction quality, particularly with regard to 4D reconstruction (i.e., gated cardiac reconstruction).