EVALUATION OF CONFIGURATION PARAMETERS FOR SLIT-SLAT COLLIMATION DESIGN

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在这个项目中，我们将使用Geant 4核科学软件包来模拟各种准直器设计参数对单光子发射计算机断层扫描（SPECT）的灵敏度和分辨率的影响。我们先前已经开发了描述几何灵敏度和分辨率的分析公式（即，没有光子穿透和散射）。我们已经开发了初步的渗透模型，需要使用计算机模拟进行验证。目前我们还没有散射模型。因此，该项目将利用Geant 4测试穿透和散射模型，以确定其对使用这种新准直器的临床发射计算机断层扫描的影响。该项目的第二个目标是开发用于改善重建质量的算法，特别是关于4D重建（即，门控心脏重建）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project, we will use the Geant4 nuclear-science package to simulate the effects of various collimator design parameters on sensitivity and resolution for single photon emission computed tomography (SPECT). We have previously developed analytic formulas that describe the geometric sensitivity and resolution (i.e., without photon penetration and scatter). We have developed preliminary models for penetration that need to be validated using computer simulation. We do not have at this time models for scatter. Thus, this project will utilize Geant4 to test models of penetration and scatter to determine their impact on clinical emission computed tomography with this new collimator. A secondary goal of this project is to develop algorithms for improved reconstruction quality, particularly with regard to 4D reconstruction (i.e., gated cardiac reconstruction).