CHARACTERIZING THE CONFORMATIONAL PREFERENCES OF P53 PEPTIDES

表征 P53 肽的构象偏好

基本信息

  • 批准号:
    7956234
  • 负责人:
  • 金额:
    $ 0.08万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-08-01 至 2010-07-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the next couple of months, I will be using my Development allocation of 30,000 Service Units (SUs) on the Teragrid to carry out molecular dynamics simulations to characterize, in atomistic detail, the conformational preferences of peptide fragments of the natively unfolded transcriptional activation domain of (TAD) tumor suppressor p53. While this Development allocation is not sufficient for me to perform all the required simulations, the simulations that I will be able to run will provide useful information for estimating my remaining computing needs on the Teragrid. With this information in mind, I will be writing a proposal for obtaining sufficient computational resources to complete the rest of the project. Results from these simulations will expand our understanding of the mechanisms by which so-called natively unfolded proteins, a.k.a. intrinsically unstructured proteins, bind to other partner proteins.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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LILLIAN T CHONG其他文献

LILLIAN T CHONG的其他文献

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{{ truncateString('LILLIAN T CHONG', 18)}}的其他基金

HIGH-PERFORMANCE WEIGHTED ENSEMBLE SOFTWARE FOR SIMULATION OF COMPLEX BIO-EVENTS
用于模拟复杂生物事件的高性能加权集成软件
  • 批准号:
    9268876
  • 财政年份:
    2015
  • 资助金额:
    $ 0.08万
  • 项目类别:
WESTPA: A high-performance framework for simulating at the frontiers of biology
WESTPA:用于模拟生物学前沿的高性能框架
  • 批准号:
    10734236
  • 财政年份:
    2015
  • 资助金额:
    $ 0.08万
  • 项目类别:
High-performance weighted ensemble software for simulation of complex bio-events
用于模拟复杂生物事件的高性能加权集成软件
  • 批准号:
    9816923
  • 财政年份:
    2015
  • 资助金额:
    $ 0.08万
  • 项目类别:
High-performance weighted ensemble software for simulation of complex bio-events
用于模拟复杂生物事件的高性能加权集成软件
  • 批准号:
    10448253
  • 财政年份:
    2015
  • 资助金额:
    $ 0.08万
  • 项目类别:
High-performance weighted ensemble software for simulation of complex bio-events
用于模拟复杂生物事件的高性能加权集成软件
  • 批准号:
    10202635
  • 财政年份:
    2015
  • 资助金额:
    $ 0.08万
  • 项目类别:
HIGH-PERFORMANCE WEIGHTED ENSEMBLE SOFTWARE FOR SIMULATION OF COMPLEX BIO-EVENTS
用于模拟复杂生物事件的高性能加权集成软件
  • 批准号:
    9306884
  • 财政年份:
    2015
  • 资助金额:
    $ 0.08万
  • 项目类别:
CHARACTERIZING THE CONFORMATIONAL PREFERENCES OF P53 PEPTIDES
表征 P53 肽的构象偏好
  • 批准号:
    7723375
  • 财政年份:
    2008
  • 资助金额:
    $ 0.08万
  • 项目类别:
FREE ENERGY ANALYSIS OF ESTEROLYTIC ANTIBODY HAPTEN COMPLEXES
酯解抗体半抗原复合物的自由能分析
  • 批准号:
    6456688
  • 财政年份:
    2001
  • 资助金额:
    $ 0.08万
  • 项目类别:
FREE ENERGY ANALYSIS OF ESTEROLYTIC ANTIBODY HAPTEN COMPLEXES
酯解抗体半抗原复合物的自由能分析
  • 批准号:
    6347850
  • 财政年份:
    2000
  • 资助金额:
    $ 0.08万
  • 项目类别:
FREE ENERGY ANALYSIS OF ESTEROLYTIC ANTIBODY HAPTEN COMPLEXES
酯解抗体半抗原复合物的自由能分析
  • 批准号:
    6220220
  • 财政年份:
    1999
  • 资助金额:
    $ 0.08万
  • 项目类别:
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