EFFECTS OF EXPLOSIVE BLAST AS COMPARED TO POST-TSD ON BRAIN FUNCTION & STRUCTURE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 爆炸冲击波颅脑损伤是现代战争的一个突出特点。我们将使用复杂的大脑功能和结构测量方法来描述2007年秋季从部署归来的伊拉克自由行动（OIF）国民警卫队士兵样本中爆炸性爆炸造成的脑损伤的特征。直接评估神经破坏的生物学措施将用于表征爆炸相关脑损伤和创伤后精神病理学之间的脑结构和功能差异。为了充分描述爆炸对大脑的影响，并将其与创伤后应激障碍区分开来，我们将暴露于爆炸的士兵组与经历创伤后应激障碍的士兵组进行对比。预计这项由美国国防部资助的研究可能需要长达四年的时间。 本研究将提供一种方法，以区分爆炸性爆炸和创伤后精神病理学造成的脑损伤和心理困扰的共同发生条件。这项研究的结果将有助于临床医生更好地区分创伤后应激障碍和爆炸性爆炸造成的脑损伤，增加我们对神经功能和结构方面的基本特征的理解。更好地区分这两种情况将使临床医生能够设计更合适的治疗方案。这项研究的结果将用于为诊断提供信息，并描述爆炸相关神经损伤后的恢复机制，以便制定干预措施，使士兵恢复最大程度的功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Brain injury from explosive blast is a prominent feature of contemporary combat. We will use sophisticated measures of brain function and structure to characterize brain injury from explosive blasts in a sample of Operation Iraqi Freedom (OIF) National Guard soldiers who returned from deployment in the fall of 2007. Biological measures that directly assess neural disruption will be used to characterize differences in brain structure and function between blast-related brain injury and post-traumatic psychopathology. To fully characterize the effects of blast on the brain and differentiate them from post-traumatic stress disorder, we will contrast groups of soldiers exposed to blast with groups experiencing post-traumatic stress disorder. It is expected that this DoD-funded study may take up to four years. This study will provide a means for separating co-occurring conditions of brain injury and psychological distress due to explosive blast and post-traumatic psychopathology. The results of this research will help clinicians better differentiate between post-traumatic stress disorder and brain injury due to explosive blast by increasing our understanding of the essential features of the conditions in terms of neural function and structure. Better differentiation between the two conditions will allow clinicians to design more appropriate treatment protocols. Results of this research will be used to inform diagnosis and characterize mechanisms of recovery after blast-related neural injury to allow the creation of interventions that return soldiers to maximum levels of functioning.