Deviant Synchronization of Neural Functions in Schizophrenia

精神分裂症神经功能同步异常

• 批准号: 9850860
• 负责人: Scott R Sponheim
• 金额: --
• 依托单位: MINNEAPOLIS VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9850860
• 关键词: Address; Architecture; Area; Basic Science; Behavioral; Biological; Bipolar Disorder; Brain; Brain region; Cerebrum; Cognitive; Cognitive deficits; Communication; Custom; Data; Diagnosis; Diagnostic; Disease; Electroencephalography; Elements; Exhibits; Failure; Feedback; Form Perception; Frequencies; Functional disorder; Funding; Genetic; Goals; Impaired cognition; Impairment; Individual; Intention; Intervention; Investigation; Laboratories; Measures; Neurophysiology - biologic function; Noise; Perception; Perceptual disturbance; Phase; Process; Psychophysics; Psychotic Disorders; Publishing; Recovery; Research; Research Personnel; Rest; Rewards; Sampling; Schizophrenia; Sensory; Series; Short-Term Memory; Siblings; Testing; Veterans; Visual; Visual Cortex; Visual Perception; Visual evoked cortical potential; Work; brain abnormalities; brain electrical activity; cognitive function; deviant; experimental study; neuropathology; neuroregulation; personalized intervention; relating to nervous system; response; sensory cortex; severe mental illness; theories; transmission process; visual process

Basic research suggests that the functional significance of synchronized neural oscillations depends on their frequency. Gamma frequencies, above 30 Hz, appear to facilitate feedforward processes that transmit basic information from sensory cortex to higher cortical regions. Frequency oscillations below 30 Hz appear to reflect the transmission of feedback information from higher cortical regions that modifies functions within sensory cortices and prioritizes elements related to behavioral goals. Although schizophrenia has been proposed to be a disorder of disturbed neural synchronization within and between brain regions, researchers have only begun to examine feedforward and feedback abnormalities reflected in the phase dynamics of electroencephalography (EEG) oscillations. The unanswered research question the proposed work addresses is whether perceptual and cognitive deficits pervasive in schizophrenia are due to deviant neural synchronization that disrupts feedforward and feedback processes within networks of the brain. The proposed work will examine aberrant neural synchronization in schizophrenia within low frequency and gamma bands during a resting state and visual perception. Through the use of visual perceptual tasks that vary in demands of feedforward and feedback processes we will test whether specific synchronization abnormalities are associated with sensory and cognitive elements of atypical visual perception in schizophrenia. Subjects will include people with schizophrenia (PSZ), biological siblings of PSZ (SibPSZ), people with bipolar disorder (PBP), biological siblings of PBP (SibPBP), and a healthy control sample (HC) to determine whether deviant oscillations are specific to schizophrenia and associated with its genetic liability. We will engage in a series of three experiments with the intention of relating deviant synchronization to a specific diagnosis of schizophrenia or to genetic liability for the disease. First, we will determine whether aberrant synchronization of resting state oscillations is present in our sample and how it segregates across diagnostic groups. Second, we will use psychophysical tasks to target low-level visual processes to investigate whether abnormal synchronization of neural oscillations provides evidence for impaired feedforward or feedback processes within visual cortex. Third, we will use form perception tasks to determine whether deviant synchronization between high cortical regions and visual cortex reflect impaired inter-areal feedforward or feedback processes. Laboratory tests that can effectively guide treatment and be used to personalize interventions have long been sought after to transform the treatment of severe mental disorders. Understanding the neural origins of cognitive and perceptual disturbances in schizophrenia will facilitate new interventions (e.g., neural modulation) to more precisely and effectively target each individual's abnormal brain function and to optimize the recovery of veterans with psychotic disorders.

基础研究表明，同步神经振荡的功能意义取决于