MULTI-PHYSICS LAYER

多物理层

• 批准号: 7956408
• 负责人: JAMES Choate SCHAFF
• 金额: $ 8.14万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956408
• 关键词: Architecture; Biological Process; Cells; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Devices; Drug Formulations; Equation; Funding; Future; Grant; Institution; Laws; Maps; Mathematics; Measurement; Modeling; Operative Surgical Procedures; Physiological; Process; Research; Research Personnel; Resources; Semantics; Source; Specific qualifier value; System; Time; Translations; United States National Institutes of Health; flexibility; mathematical model; physical model; research study; virtual

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In order to support the required flexibility and future extensibility of our generalized PSE architecture, an additional physical modeling layer will be introduced. The current Virtual Cell features a direct transformation from a domain-specific quantitative process description (the physiological model consisting of chemical, electrophysiological, and transport mechanisms) and user specified assumptions directly to a purely mathematical model. Implicit in this transformation from biological processes to mathematics are the choice of specific physical approximations, geometric mappings, time scales, and the underlying physical laws. The addition of additional modeling domains as well as explicit models of measurement devices (e.g. virtual experiments) call out for an intermediate physical layer where all processes (and equations) are explicit, but still map one-to-one with the process descriptions. The translation from interconnected "physical devices" to solvable systems of equations is then isolated from the formulation of a physically consistent model. Embedded in this layer are the semantics of physical consistency along with those of mathematical consistency. We will define the semantics and operations of this physical layer and provide a reference implementation (allowing for alternate representations such as CellML and Modelica). The specification of this layer provides room for specialized and sophisticated mathematical transformations to transform the physical/mathematical systems into a solvable form.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 为了支持所需的灵活性和未来的扩展性，我们的广义PSE架构，一个额外的物理建模层将被引入。 当前的虚拟细胞具有从特定领域的定量过程描述（由化学、电生理和运输机制组成的生理模型）和用户指定的假设直接转换为纯数学模型的功能。 从生物学过程到数学的这种转变中隐含着对特定物理近似、几何映射、时间尺度和基本物理定律的选择。 添加额外的建模域以及测量设备的显式模型（例如虚拟实验）需要一个中间物理层，其中所有过程（和方程）都是显式的，但仍然与过程描述一一对应。 从相互连接的“物理设备”到可解方程组的转换，然后从物理上一致的模型的制定中分离出来。 物理一致性的语义沿着数学一致性的语义嵌入在这一层中。 我们将定义这个物理层的语义和操作，并提供一个参考实现（允许其他表示，如CellML和Modelica）。 这一层的规范为专门和复杂的数学转换提供了空间，以将物理/数学系统转换为可解形式。