STRUCTURE OF THE COPII VESICULAR CAGE

COPII 囊泡笼的结构

• 批准号: 7955193
• 负责人: JONATHAN GOLDBERG
• 金额: $ 0.13万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955193
• 关键词: Biochemical; Computer Retrieval of Information on Scientific Projects Database; Encapsulated; Endoplasmic Reticulum; Funding; Goals; Grant; Institution; Molecular Models; Proteins; Research; Research Personnel; Resources; Series; Source; Structure; Transport Vesicles; United States National Institutes of Health; Vesicle; molecular modeling; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this research is to construct a molecular model of the COPII vesicle cage, a 3-megadalton assembly that encapsulated transport vesicles forming on the endoplasmic reticulum. Through biochemical analysis, we have defined a series of subassemblies of the COPII cage proteins Sec13/Sec31, and we successfully obtained two crystal forms that together constitute the entire assembly unit of the vesicular cage.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目标是构建COPII囊泡笼子的分子模型，COPII囊泡笼子是一个300万吨的组件，包裹着内质网上形成的运输囊泡。通过生化分析，我们定义了COPII笼蛋白Sec13/Sec31的一系列亚组分，并成功地获得了两种晶型，它们共同构成了囊泡笼子的整个组装单元。