STRUCTURE OF THE COPII VESICULAR CAGE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项工作的目的是确定囊泡外壳蛋白与货物运输信号、ARF家族GTP酶和SNARE蛋白结合的关键复合体的晶体结构。我们主要关注参与内质网到高尔基体囊泡运输的COPII涂层，以及参与高尔基体囊泡萌发的COPI涂层。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this work is to determine the crystal structures of key complexes of vesicle coat proteins bound to cargo transport signals, ARF-family GTPases and SNARE proteins. We are focusing primarily on the COPII coat complex that participates in ER-to-Golgi vesicular trafficking, and the COPI coat that functions in vesicle budding from the Golgi apparatus.