STRUCTURAL AND MECHANISTIC STUDIES OF THE PANTOCIN A BIOSYNTHESIS

全解菌素A生物合成的结构和机理研究

• 批准号: 7955137
• 负责人: Jon Clardy
• 金额: $ 2.14万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955137
• 关键词: Affect; Anabolism; Antibiotics; Apple; Biochemistry; Computer Retrieval of Information on Scientific Projects Database; Disease; Erwinia amylovora; Fire - disasters; Funding; Gram-Negative Bacteria; Grant; Growth; Institution; Pantoea agglomerans; Pear; Peptides; Plant Diseases; Plants; Research; Research Personnel; Resources; Source; Trees; United States National Institutes of Health; base; novel; pantocin A; structural biology; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Fire blight is a devastating plant disease that is caused by Erwinia amylovora, a Gram-negative bacterium. The disease affects more than a hundred rosaceous plant species, including the commercially important apple and pear trees. Pantocin A is a novel peptide-based antibiotic produced by Pantoea agglomerans, another Gram-negative bacterium, to inhibit the growth of E. amylovora. This project attempts to utilize both structural biology and biochemistry tools to elucidate the biosynthesis of pantocin A.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 火疫病是一种毁灭性的植物疾病，由革兰氏阴性细菌淀粉欧文氏菌引起。这种疾病影响了100多种玫瑰科植物，包括具有重要商业价值的苹果树和梨树。泛素A是由另一种革兰氏阴性菌--聚集性泛胞杆菌生产的一种新型多肽类抗生素，用于抑制淀粉菌的生长。本项目试图利用结构生物学和生物化学工具来阐明泛素A的生物合成。