WALL TEICHOIC ACID BIOSYNTHESIS: A NEW TARGET FOR THERAPEUTIC INTERVENTION?

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该子项目涉及B中参与壁磷壁酸生物合成的酶的机制和结构研究。枯草杆菌。 我们的目的是确定壁磷壁酸途径在S。金黄色葡萄球菌，一种主要的革兰氏阳性病原体，并开发一种体外靶向筛选抑制剂。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This subproject involves mechanistic and structural investigations of enzymes involved in wall teichoic acid biosynthesis in B. subtilis. Our aim is to define the wall teichoic acid pathway in S. aureus, a major Gram-positive pathogen, and to develop an invitro target-based screen for inhibitors.