MECHANISM AND INHIBITION OF BACTERIAL TRANSGLYCOSYLASES

细菌转糖基酶的机制和抑制

• 批准号: 7955184
• 负责人: SUZANNE WALKER
• 金额: $ 3.29万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955184
• 关键词: Anabolism; Bambermycins; Binding; Biological Factors; Cell Wall; Clinical; Computer Retrieval of Information on Scientific Projects Database; Enzyme Inhibition; Enzymes; Funding; Grant; Institution; Peptidoglycan; Peptidoglycan glycosyltransferase; Polysaccharides; Property; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; analog; design; improved; moenomycin A; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Moenomycin A (MmA) is the natural product that inhibits bacterial cell wall biosynthesis by binding to the peptidoglycan glycosyltransferases (PGTs), the enzymes that make the glycan chains of peptidoglycan. MmA is remarkably potent, but its clinical utility has been hampered by its poor physicochemical properties. A better understanding of the roles of particular structural features in enzyme inhibition may ultimately enable the design of moenomycin analogs with improved properties.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 莫诺霉素A(MMA)是一种天然产物，通过与肽聚糖糖基转移酶(PGTS)结合来抑制细菌细胞壁的生物合成，PGTS是构成肽聚糖糖链的酶。MMA是非常有效的，但由于其糟糕的物理化学性质，其临床应用一直受到阻碍。更好地了解特定结构特征在酶抑制中的作用最终可能使设计具有更好性能的莫诺霉素类似物成为可能。