PITT-MCRC for Rheumatic and Musculoskeletal Diseases

描述（由申请人提供）： 该多学科临床研究中心 (PITT-MCRC) 申请要求扩大匹兹堡大学关节炎研究所的临床研究部分。该提案建立在匹兹堡大学风湿病和肌肉骨骼疾病方面强大的跨学科研究基础以及关节炎研究所过去 8 年的成功基础之上。 PITT-MCRC研究基地目前由67名首席研究员的140个独立资助的研究项目组成。 PITT-MCRC 研究基地的成员在校外资助方面有着出色的记录，目前获得超过 5400 万美元的联邦和非联邦拨款（每年直接费用）的支持。 PITT-MCRC 将支持三个解决非常重要的临床问题的临床研究项目、一个管理核心项目和一个方法学核心项目。这三个临床研究项目涉及以下学科：成人和儿童风湿病学、计算机科学、卫生服务研究、卫生经济学、少数民族健康、老年病学和流行病学。 这些项目是： 项目 1 - 幼年类风湿性关节炎 (JRA) 的定量结果测量；项目 2 - 关节置换的差异：干预途径；项目 3 - 炎症与衰老：老年女性的细胞因子、骨质流失和骨折；和项目 4 - 图像引导关节软骨清创术。 拟议的 PITT-MCRC 的两个核心将提供基础设施：i) 促进关节炎和肌肉骨骼疾病的多学科临床研究，ii) 提供研究设计和生物统计支持，iii) 鼓励新方法的开发，以及 iv) 促进实习生和初级教员的教育和发展。除了为申请中包含的四个临床研究项目提供支持外，PITT-MCRC还将促进匹兹堡大学风湿病和肌肉骨骼疾病临床研究项目的持续增长和生产力。

DESCRIPTION (provided by applicant): This Multidisciplinary Clinical Research Center (PITT-MCRC) application requests the expansion of the clinical research component of the University of Pittsburgh Arthritis Institute. This proposal builds on the strong interdisciplinary research base in rheumatic and musculoskeletal diseases at the University of Pittsburgh and on the success of the Arthritis Institute over the past 8 years. The PITT-MCRC research base currently consists of 140 independently funded research projects from 67 Principal Investigators. Members of the PITT-MCRC research base have an outstanding record of established extramural funding and are currently supported by federal and non-federal grants in excess of $54 million (annual direct costs). The PITT-MCRC will support three clinical research projects that address highly important clinical problems, an Administrative Core, and a Methodology Core. The three clinical research projects involve the following disciplines: adult and pediatric rheumatology, computer science, health services research, health economics, minority health, geriatrics, and epidemiology. These projects are: Project 1 - Quantitative Outcome Measures for Juvenile Rheumatoid Arthritis (JRA); Project 2 - Disparity in Joint Replacement: Pathway to Intervention; Project 3 - Inflammation and Aging: Cytokines, Bone Loss, and Fracture in Older Women; and Project 4 - Image Guided Debridement of Articular Cartilage. The two Cores of the proposed PITT-MCRC will provide the infrastructure to: i) promote multidisciplinary clinical research in arthritis and musculoskeletal diseases, ii) provide study design and biostatistical support, iii) encourage the development of new methodologies, and iv) foster trainee and junior faculty education and development. In addition to the support that it will provide for the four clinical research projects included in the application, the PITT-MCRC will foster the continued growth and productivity of the clinical research programs in rheumatic and musculoskeletal diseases at the University of Pittsburgh.