Clinical Centers for the Osteoarthritis Initiative

骨关节炎倡议临床中心

• 批准号: 7942203
• 负责人: C KENT KWOH
• 金额: $ 118.4万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2014-10-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7942203
• 关键词: Clinical; Centers; Osteoarthritis; Initiative

Knee osteoarthritis (OA) is the most common cause of disability in adults. The "Osteoarthritis Initiative (OAI): A Knee Health Study" is a nationwide research study that will help researchers gather more information about the physical changes that occur prior to the onset of arthritis symptoms or before OA gets worse. The purpose of this study is to examine people who have knee OA or are at high risk for knee OA; information will be used to better understand how to prevent and treat knee OA Knee OA causes more health problems and medical expenses that any other form of arthritis. Symptoms of OA can range from stiffness and mild pain to severe joint pain and even disability. Previous research has shown that certain factors, such as knee pain, prior knee injury or knee surgery, OA of the hand, or obesity, may lead to knee OA. The OAI is a multicenter, observational study of knee OA that will collect information on potential biomarkers for OA and trends in OA onset and progression. The OAI will recruit and follow participants who have knee OA or are at high risk for developing knee OA for at least a four-year period at one of four clinical centers. Blood and urine collection, magnetic resonance imaging (MRI), and X-rays will be completed at each of four annual follow-up visits. A questionnaire and physical examination at screening will assess for risk factors for the development and progression of knee OA. Levels of knee pain and physical disability will be assessed at study start and at each of the follow-up visits by questionnaire and examination.

膝骨性关节炎(OA)是导致成年人残疾的最常见原因。“骨关节炎倡议(OAI)：膝关节健康研究”是一项全国性的研究，将帮助研究人员收集更多关于关节炎症状出现之前或OA恶化之前发生的身体变化的信息。这项研究的目的是检查患有膝骨性关节炎或膝骨性关节炎高危人群；信息将被用来更好地了解如何预防和治疗膝骨性关节炎膝骨性关节炎比任何其他形式的关节炎引起更多的健康问题和医疗费用。骨性关节炎的症状可以从僵硬和轻微疼痛到严重的关节疼痛甚至残疾。先前的研究表明，某些因素，如膝关节疼痛、既往膝关节损伤或膝关节手术、手部骨关节炎或肥胖，可能会导致膝关节骨性关节炎。OAI是一项关于膝骨性关节炎的多中心观察性研究，它将收集有关骨性关节炎潜在生物标志物以及骨性关节炎发病和进展趋势的信息。OAI将在四个临床中心之一招募和跟踪患有膝骨性关节炎或膝骨性关节炎高风险的参与者至少四年。血液和尿液采集、核磁共振成像(MRI)和X光检查将在四次年度随访中的每一次完成。筛查时的问卷调查和体格检查将评估膝骨性关节炎的发展和进展的危险因素。膝关节疼痛和身体残疾的程度将在研究开始时和每次随访时通过问卷和检查进行评估。