JOINT LOADING AND THE PROGRESSION OF OSTEOARTHRITIS FOLLOWING TKA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 全膝关节置换术（TKA）是美国最常见的膝关节手术之一。TKA患者在功能任务中表现出定性和定量缺陷。在接受体重时，步幅缩短和膝关节活动受限是TKA后的常见结果。在接受TKA的个体中，持续残疾和异常运动模式的原因尚不清楚，但股四头肌无力可能是一个原因。股四头肌无力是TKA术后常见的持续性损伤，与老年人的功能表现差相关。即使在膝关节置换术后数年，虚弱也经常明显，与年龄匹配的对照组相比，缺陷范围为30%至40%。这项工作的总体目标是确定TKA后肢体之间股四头肌力量正常化的康复是否会导致髋关节和膝关节的对称负荷，并最终减少初次TKA后对侧髋关节和膝关节OA的进展。斯奈德-麦克勒博士是一名全职教授，不会有导师。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Total knee arthroplasty (TKA) is one of the most common knee surgeries performed in the United States. Patients with TKA exhibit qualitative and quantitative deficits in functional tasks. Shortened stride length and limited knee excursion during weight acceptance is a common finding after TKA. The cause of persistent disability and aberrant movement patterns in individuals who have undergone TKA is unclear, but quadriceps weakness is a likely contributor. Quadriceps weakness is a common and persistent impairment after TKA and has been correlated with poor functional performance in older adults. Weakness is often pronounced even years after knee replacement surgery with deficits ranging from 30% to 40% when compared to age-matched comparison groups. The overall goal of this work is to determine if rehabilitation that normalizes quadriceps strength between limbs after TKA will result in symmetrical loading of the hips and knees and ultimately decrease the progression of contralateral hip and knee OA after primary TKA. Dr. Snyder-Mackler is a full professor and will not have a mentor.