JOINT LOADING AND THE PROGRESSION OF OSTEOARTHRITIS FOLLOWING TKA

TKA 后的关节负荷和骨关节炎的进展

• 批准号: 7959493
• 负责人: LYNN SNYDER-MACKLER
• 金额: $ 25.52万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959493
• 关键词: Age; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Contralateral; Degenerative polyarthritis; Elderly; Engineering; Exhibits; Funding; Goals; Grant; Hip region structure; Impairment; Individual; Institution; Joints; Knee; Length; Limb structure; Mentors; Movement; Operative Surgical Procedures; Patients; Pattern; Performance; Rehabilitation therapy; Research; Research Personnel; Resources; Science; Source; United States; United States National Institutes of Health; Weight; Woman; Work; comparison group; disability; knee replacement arthroplasty; professor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Total knee arthroplasty (TKA) is one of the most common knee surgeries performed in the United States. Patients with TKA exhibit qualitative and quantitative deficits in functional tasks. Shortened stride length and limited knee excursion during weight acceptance is a common finding after TKA. The cause of persistent disability and aberrant movement patterns in individuals who have undergone TKA is unclear, but quadriceps weakness is a likely contributor. Quadriceps weakness is a common and persistent impairment after TKA and has been correlated with poor functional performance in older adults. Weakness is often pronounced even years after knee replacement surgery with deficits ranging from 30% to 40% when compared to age-matched comparison groups. The overall goal of this work is to determine if rehabilitation that normalizes quadriceps strength between limbs after TKA will result in symmetrical loading of the hips and knees and ultimately decrease the progression of contralateral hip and knee OA after primary TKA. Dr. Snyder-Mackler is a full professor and will not have a mentor.

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