JOINT LOADING AND THE PROGRESSION OF OSTEOARTHRITIS FOLLOWING TKA

TKA 后的关节负荷和骨关节炎的进展

• 批准号: 8359773
• 负责人: LYNN SNYDER-MACKLER
• 金额: $ 27.65万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359773
• 关键词: Age; Centers of Research Excellence; Contralateral; Degenerative polyarthritis; Elderly; Engineering; Exhibits; Funding; Goals; Grant; Hip region structure; Impairment; Individual; Knee; Length; Limb structure; Mentors; Movement; National Center for Research Resources; Operative Surgical Procedures; Patients; Pattern; Performance; Principal Investigator; Rehabilitation therapy; Research; Research Infrastructure; Resources; Science; Source; United States; United States National Institutes of Health; Weight; Woman; Work; comparison group; cost; disability; joint loading; knee replacement arthroplasty; professor; quadriceps muscle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Total knee arthroplasty (TKA) is one of the most common knee surgeries performed in the United States. Patients with TKA exhibit qualitative and quantitative deficits in functional tasks. Shortened stride length and limited knee excursion during weight acceptance is a common finding after TKA. The cause of persistent disability and aberrant movement patterns in individuals who have undergone TKA is unclear, but quadriceps weakness is a likely contributor. Quadriceps weakness is a common and persistent impairment after TKA and has been correlated with poor functional performance in older adults. Weakness is often pronounced even years after knee replacement surgery with deficits ranging from 30% to 40% when compared to age-matched comparison groups. The overall goal of this work is to determine if rehabilitation that normalizes quadriceps strength between limbs after TKA will result in symmetrical loading of the hips and knees and ultimately decrease the progression of contralateral hip and knee OA after primary TKA. Dr. Snyder-Mackler is a full professor and will not have a mentor.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 全膝关节置换术（TKA）是美国最常见的膝关节手术之一。 TKA 患者在功能任务中表现出定性和定量缺陷。 TKA 术后常见的现象是接受重量时步幅缩短和膝关节偏移有限。接受全膝关节置换术的患者出现持续性残疾和异常运动模式的原因尚不清楚，但股四头肌无力可能是一个原因。股四头肌无力是全膝关节置换术后常见且持续的损伤，与老年人功能表现不佳相关。即使在膝关节置换手术数年后，肌无力也常常很明显，与年龄匹配的对照组相比，肌无力程度从 30% 到 40% 不等。这项工作的总体目标是确定 TKA 后四肢之间股四头肌力量正常化的康复是否会导致髋部和膝部的对称负载，并最终减少初次 TKA 后对侧髋部和膝部 OA 的进展。斯奈德-麦克勒博士是一名正教授，不会有导师。